Results 121 to 130 of about 22,216 (225)
Haematologica, 2019 Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1 ...
Kimberly N. Smitheman +19 more
doaj +1 more source
Control of developmentally primed erythroid genes by combinatorial co-repressor actions [PDF]
, 2015 How transcription factors (TFs) cooperate within large protein complexes to allow rapid modulation of gene expression during development is still largely unknown.
Andrieu-Soler, C +18 more
core +4 more sources
Cell Reports, 2014 Summary: Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.
Changmeng Cai +15 more
doaj +1 more source
Research progress of LSD1 in regulating tumor immune mechanisms [PDF]
Jichu yixue yu linchuangLysine-specific demethylase 1(LSD1) plays a regulatory role in tumor immunity. LSD1 affects CD8+T cell infiltration by regulating AGO2 protein level, and it is required for normal B cell proliferation and differentiation via reducing local chromatin ...
LONG Lijuan, SONG Songze, YE Qinong, LIN Jing
doaj +1 more source
LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer
Clinical Epigenetics, 2017 Background Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a
Sebastiano Battaglia +7 more
doaj +1 more source
PLoS ONE, 2013 Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis. Hepatocyte nuclear factor 4α (HNF4α) and α1-fetoprotein transcription factor (FTF) are two major transcription factors driving CYP7A1 promoter activity in hepatocytes.
Huafang Ouyang +4 more
openaire +4 more sources
Clinical and Translational MedicineBackground Immune checkpoint blockade, particularly targeting programmed death 1 (PD‐1) and programmed death ligand 1 (PD‐L1), shows promise in treating hepatocellular carcinoma (HCC).
Chen Liang +23 more
doaj +1 more source
Scientific Reports, 2017 Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory.
Chae-Seok Lim +20 more
doaj +1 more source
LSD1 is required for chromosome segregation during mitosis
European Journal of Cell Biology, 2010 Dynamic methylation/demethylation of histones and non-histone proteins occurs during the cell cycle. Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).
Shuang, Lv +8 more
openaire +2 more sources
The scaffolding function of LSD1 controls DNA methylation in mouse ESCs
Nature CommunicationsLysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development.
Sandhya Malla +24 more
doaj +1 more source