Results 141 to 150 of about 12,312 (182)
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Discovery of acridine-based LSD1 inhibitors as immune activators targeting LSD1 in gastric cancer
European Journal of Medicinal Chemistry, 2023LSD1 is overexpressed in various cancers and promotes tumor cell proliferation, tumor expansion, and suppresses immune cells infiltration and is closely associated with immune checkpoint inhibitors therapy. Therefore, the inhibition of LSD1 has been recognized as a promising strategy for cancer therapy.
Hui-Min Liu +8 more
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Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1
Journal of Medicinal Chemistry, 2021As a flavin adenine dinucleotide (FAD)-dependent monoamine oxidase, lysine specific demethylase 1 (LSD1/KDM1A) functions as a transcription coactivator or corepressor to regulate the methylation of histone 3 lysine 4 and 9 (H3K4/9), and it has emerged as a promising epigenetic target for anticancer treatment. To date, numerous inhibitors targeting LSD1
Xing-Jie Dai +6 more
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LSD1 inhibition: a therapeutic strategy in cancer?
Expert Opinion on Therapeutic Targets, 2012The role of epigenetic dysfunction in cancer is increasingly appreciated. This has raised the question as to whether enzymes that regulate the structure and function of chromatin might represent novel therapeutic targets. The histone demethylase LSD1 is one such candidate and novel, potent inhibitors are under development.The literature on LSD1 (also ...
Lynch, James T. +2 more
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Annual review of LSD1/KDM1A inhibitors in 2020
European Journal of Medicinal Chemistry, 2021, Bin Yu, Bin Yu
exaly
METHODS OF TREATING LSD1-RELATED DISEASES and Disorders WITH LSD1 INHIBITORS
2021HITOTSUMACHI HIROKO +4 more
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Targeting LSD1 for acute myeloid leukemia (AML) treatment
Pharmacological Research, 2021Yongfang Yao, Hong-Min Liu, Bin Yu
exaly
Therapeutic potential of targeting LSD1/ KDM1A in cancers
Pharmacological Research, 2022Dongmei Zhao +2 more
exaly
CSF3R and SETBP1 getting high on LSD1
Blood, 2022Helong Zhao, Michael W. Deininger
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Coaching LSD1 to ignore acetylation
Nature Chemical BiologyJoshua C. Black, Tatiana G. Kutateladze
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