Results 151 to 160 of about 27,519 (289)

Research progress of LSD1 in regulating tumor immune mechanisms [PDF]

Jichu yixue yu linchuang
Lysine-specific demethylase 1(LSD1) plays a regulatory role in tumor immunity. LSD1 affects CD8+T cell infiltration by regulating AGO2 protein level, and it is required for normal B cell proliferation and differentiation via reducing local chromatin ...
LONG Lijuan, SONG Songze, YE Qinong, LIN Jing
doaj   +1 more source

Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells

Scientific Reports
Lysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene ...
Sandhya Malla, Carlos Martinez-Gamero, Kanchan Kumari, Cyrinne Achour, Georgios Mermelekas, David Martinez-Delgado, Alba Coego, Diana Guallar, Angel-Carlos Roman, Francesca Aguilo   +9 more
doaj   +1 more source

Lysine‐specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti‐programmed death 1 therapy in liver cancer

Clinical and Translational Medicine
Background Immune checkpoint blockade, particularly targeting programmed death 1 (PD‐1) and programmed death ligand 1 (PD‐L1), shows promise in treating hepatocellular carcinoma (HCC).
Chen Liang, Mu Ye, Lei Yu, Peng‐Fei Zhang, Xiao‐Jun Guo, Xian‐Long Meng, Hai‐Ying Zeng, Shu‐Yang Hu, Dao‐Han Zhang, Qi‐Man Sun, Ying‐Hao Shen, Jia‐Bin Cai, Shuang‐Qi Li, Zhen Chen, Ying‐Hong Shi, Ai‐Wu Ke, Yujiang G. Shi, Jian Zhou, Jia Fan, Fei‐Zhen Wu, Xiao‐Yong Huang, Guo‐Ming Shi, Zheng Tang, Jia‐Cheng Lu   +23 more
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Prox1 Directly Interacts with LSD1 and Recruits the LSD1/NuRD Complex to Epigenetically Co-Repress CYP7A1 Transcription

PLoS ONE, 2013
Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis. Hepatocyte nuclear factor 4α (HNF4α) and α1-fetoprotein transcription factor (FTF) are two major transcription factors driving CYP7A1 promoter activity in hepatocytes.
Huafang Ouyang, Yi Qin, Yanfeng Liu, Youhua Xie, Jing Liu   +4 more
openaire   +4 more sources

PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

Scientific Reports, 2017
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory.
Chae-Seok Lim, Hye Jin Nam, Jaehyun Lee, Dongha Kim, Ja Eun Choi, SukJae Joshua Kang, Somi Kim, Hyopil Kim, Chuljung Kwak, Kyu-Won Shim, Siyong Kim, Hyoung-Gon Ko, Ro Un Lee, Eun-Hae Jang, Juyoun Yoo, Jaehoon Shim, Md Ariful Islam, Yong-Seok Lee, Jae-Hyung Lee, Sung Hee Baek, Bong-Kiun Kaang   +20 more
doaj   +1 more source

LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer

Clinical Epigenetics, 2017
Background Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a
Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T. Moser, Dominic J Smiraglia, Barbara A. Foster   +7 more
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P1649: GFI1B AND LSD1 REPRESS A MYELOID DIFFERENTIATION PROGRAM DURING INDUCED PLURIPOTENT STEM CELL DERIVED MEGAKARYOCYTE DIFFERENTIATION

, 2022
J. Venhuizen, M. van Bergen, D. Gilissen, Laura Wingens, Emile van den Akker, J. Jansen, Joost H.A. Martens, Bert van der Reijden   +7 more
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Supplementary Table 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

, 2023
William M. Yashar, Brittany M. Curtiss, Daniel J. Coleman, Jake VanCampen, Garth Kong, Jommel Macaraeg, Joseph Estabrook, Emek Demir, Nicola Long, Daniel Bottomly, Shannon K. McWeeney, Jeffrey Tyner, Brian Druker, Julia E. Maxson, Theodore P. Braun   +14 more
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LSD1 is required for chromosome segregation during mitosis

European Journal of Cell Biology, 2010
Dynamic methylation/demethylation of histones and non-histone proteins occurs during the cell cycle. Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).
Shuang, Lv, Wenjuan, Bu, Hong, Jiao, Bo, Liu, Lin, Zhu, Hongchang, Zhao, Ji, Liao, Jing, Li, Xingzhi, Xu   +8 more
openaire   +2 more sources

Supplementary Figure S3 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

, 2023
Chungang Liu, Limei Liu, Xuejiao Chen, Jiamin Cheng, Heng Zhang, Chengcheng Zhang, Juanjuan Shan, Junjie Shen, Cheng Qian   +8 more
openalex   +2 more sources