Results 51 to 60 of about 12,929 (212)

Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level

Advanced Science, EarlyView.
A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E, Lijiang Fei, Jingjing Wang, Xinru Wang, Renying Wang, Xueyi Wang, Peijing Zhang, Jianhui Chen, Junqing Wu, Mengmeng Jiang, Daosheng Huang, Danmei Jia, Guoji Guo, Xiaoping Han   +13 more
wiley   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4

Neoplasia: An International Journal for Oncology Research, 2020
Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer. Importantly, our recent work examining metastatic biopsy samples demonstrates NEPC is increasing in frequency.
Daniel J. Coleman, David A. Sampson, Archana Sehrawat, Anbarasu Kumaraswamy, Duanchen Sun, Yuzhuo Wang, Jacob Schwartzman, Joshua Urrutia, Ahn R. Lee, Ilsa M. Coleman, Peter S. Nelson, Xuesen Dong, Colm Morrissey, Eva Corey, Zheng Xia, Joel A. Yates, Joshi J. Alumkal   +16 more
doaj  

Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, and Bel-7402).
Lijuan Ding, Feng Wei, Nanya Wang, Yue Sun, Qiang Wang, Xia Fan, Ling Qi, Shudong Wang   +7 more
doaj   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program

Cell Reports, 2016
Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of
Audrey Sambeat, Olga Gulyaeva, Jon Dempersmier, Kevin M. Tharp, Andreas Stahl, Sarah M. Paul, Hei Sook Sul   +6 more
doaj   +1 more source

Aminotriazole and Aminotetrazole Inhibitors of LSD1 as Epigenetic Modulators [PDF]

ACS Medicinal Chemistry Letters, 2015
Aminotriazole and Aminotetrazole Inhibitors of LSD1 as Epigenetic Modulators Vijay Kumar* and Gerard Rosse* Dart Neuroscience LLC, Structure Guided Chemistry, 12278 Scripps Summit Drive, San Diego, California 92131, United States Adjunct Associate Professor, Department of Pharmacology and Physiology, College of Medicine, Drexel University, New College ...
Vijay Kumar, Gérard Rossé
openalex   +4 more sources

Krüppel‐like factor 4 transcription factor in blood–brain barrier endothelial cells: A potential role in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei, Chunhua Liu, Jianyu Chen, Yuxiao Yao, Dajiang Qin   +4 more
wiley   +1 more source

An Engineered Biocatalyst for Enantioselective Hydrazone Reduction

Angewandte Chemie International Edition, Accepted Article.
Enantioselective reduction of hydrazones provides a convergent and versatile route to synthesize hydrazine‐containing motifs that are commonly found in pharmaceuticals and agrochemicals. However current methods require the use of precious metals, costly chiral ligands and/or forcing reaction conditions. Here, we report the development of a biocatalytic
Anthony P. Green, Amy E. Hutton, Fei Zhao, Elizabeth Ho, Jack Domenech, Vanessa Harawa, Murray J. B. Brown, Gideon Grogan, Phillip D. Clayman, Nicholas J. Turner   +9 more
wiley   +1 more source

LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer

Biochemistry and Biophysics Reports, 2017
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by rapid progression. The mechanisms that lead to a shift from initial therapeutic sensitivity to ultimate therapeutic resistance are poorly understood. Although the SCLC genomic landscape led to the discovery of promising agents targeting genetic alterations that were ...
Aditya Wirawan, Kazuhiro Yatera, Shinji Kohsaka, Ryota Kanemaru, Hiroshi Mukae, Tsuyoshi Saito, Shigehiro Yagishita, Kazuhisa Takahashi, Kaoru Mogushi, Shinya Kojima, Fumiyuki Takahashi, Keiko Mitani, Takanobu Jotatsu, Ken Tajima, Kazuya Takamochi, Naoko Shimada, Ryo Ko, Kenji Suzuki, Moulid Hidayat   +18 more
openaire   +4 more sources