Results 11 to 20 of about 22,985 (275)
Sos2 is dispensable for NMDA-induced Erk activation and LTP induction [PDF]
Neuroscience Letters, 2009 N-methyl-d-aspartate (NMDA) receptor-induced activation of extracellular signal-related protein kinase (Erk) plays important roles in various neuronal functions including long-term potentiation (LTP). Son of sevenless (Sos) proteins have been implicated in NMDA-induced Erk activation in neurons of young mice.
Junko Arai, Shaomin Li, Larry A. Feig
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LTP induction by structural rather than enzymatic functions of CaMKII. [PDF]
Nature, 2023 AbstractLearning and memory are thought to require hippocampal long-term potentiation (LTP), and one of the few central dogmas of molecular neuroscience that has stood undisputed for more than three decades is that LTP induction requires enzymatic activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII)1–3.
Tullis JE +10 more
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LTP induction modifies functional relationship among hippocampal neurons [PDF]
Learning & Memory, 2007 To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered ‘functional connectivity,’ as defined by the degree of synchronous firing, among ...
Sung Hwan Yun +5 more
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LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia. [PDF]
Neuron, 2020 Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic glutamate actions is ...
Henneberger C +22 more
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Dendritic spike induction of postsynaptic cerebellar LTP [PDF]
Nature Precedings, 2008 AbstractThe architecture of parallel fiber (PF) axons contacting cerebellar Purkinje neurons (PNs) retains spatial information over long distances. PF synapses can trigger local dendritic calcium spikes, but whether and how this calcium signal leads to plastic changes that decode the PF input organization is unknown.
Marco Canepari, Kaspar E. Vogt
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Induction and expression of GluA1 (GluR‐A)‐independent LTP in the hippocampus [PDF]
European Journal of Neuroscience, 2009 AbstractLong‐term potentiation (LTP) at hippocampal CA3–CA1 synapses is thought to be mediated, at least in part, by an increase in the postsynaptic surface expression of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole proprionic acid (AMPA) receptors induced byN‐methyl‐d‐aspartate (NMDA) receptor activation.
Carola Romberg +7 more
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NMDAR LTP and LTD induction: 2B or Not 2B...is that the question? [PDF]
Debates in Neuroscience, 2007 NMDA receptor (NMDAR) dependent forms of synaptic plasticity are thought to play critical roles in many aspects of CNS function and dysfunction, from learning and memory to addiction. NMDARs are heteromeric tetramers principally comprised of two NR1 subunits and two of four varieties of NR2 subunits (NR2A-2D).
Thomas L. Kash, Danny G. Winder
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Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination [PDF]
Journal of Neurochemistry, 2001 Hippocampal long‐term potentiation (LTP) is a robust and long‐lasting form of synaptic plasticity that is the leading candidate for a cellular mechanism contributing to mammalian learning and memory. Investigations over the past decade have revealed that the biochemistry of LTP induction involves mechanisms of great subtlety and complexity. This review
Kelly T. Dineley +5 more
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Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. [PDF]
PLoS ONE, 2011 Fear memory formation is thought to require dopamine, brain-derived neurotrophic factor (BDNF) and zinc release in the basolateral amygdala (BLA), as well as the induction of long term potentiation (LTP) in BLA principal neurons.
Chenchen Li +3 more
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A PARP1-ERK2 synergism is required for the induction of LTP [PDF]
Scientific Reports, 2016 AbstractUnexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, was also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecular mechanism based on PARP1-Erk synergism, which may underlie this phenomenon.
Visochek, L +14 more
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