Results 11 to 20 of about 47,591 (317)
An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction. [PDF]
Front Mol Neurosci, 2018 The small GTPase Rac1 promotes actin polymerization and plays a critical and increasingly appreciated role in the development and plasticity of glutamatergic synapses. Growing evidence suggests that disruption of the Rac1 signaling pathway at glutamatergic synapses contributes to Autism Spectrum Disorder/intellectual disability (ASD/ID)-related ...
Tian C +5 more
europepmc +6 more sources
Dendritic spike induction of postsynaptic cerebellar LTP [PDF]
Nature Precedings, 2008 The architecture of parallel fiber (PF) axons contacting cerebellar Purkinje neurons (PNs) retains spatial information over long distances. PF synapses can trigger local dendritic calcium spikes, but whether and how this calcium signal leads to plastic ...
Kaspar E. Vogt, Marco Canepari
core +3 more sources
Induction of LTP mechanisms in dually innervated dendritic spines
Scientific ReportsDendritic spines are the postsynaptic compartments of excitatory synapses, however, a substantial subset of spines additionally receives inhibitory input.
Jonathan E. Tullis, K. Ulrich Bayer
doaj +3 more sources
Exploring new roles for actin upon LTP induction in dendritic spines. [PDF]
Sci Rep, 2021 Abstract Dendritic spines, small protrusions of the dendrites, enlarge upon LTP induction, linking morphological and functional properties. Although the role of actin in spine enlargement has been well studied, little is known about its relationship with mechanical membrane properties, such as membrane tension, which is involved in ...
Bonilla-Quintana M, Wörgötter F.
europepmc +9 more sources
Correction to: Optical monitoring of glutamate release at multiple synapses in situ detects changes following LTP induction. [PDF]
Mol Brain, 2020 Kopach O, Zheng K, Rusakov DA.
europepmc +2 more sources
Olfactory learning-induced enhancement of the predisposition for LTP induction [PDF]
Learning & Memory, 2011 Learning of a particularly difficult olfactory-discrimination (OD) task results in acquisition of rule learning. This enhancement in learning capability is accompanied by the long-term enhancement of synaptic connectivity between piriform cortex pyramidal neurons. In this study we examined whether olfactory rule learning would modify the predisposition
Yaniv Cohen +3 more
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A PARP1-ERK2 synergism is required for the induction of LTP [PDF]
Scientific Reports, 2016 AbstractUnexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, was also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecular mechanism based on PARP1-Erk synergism, which may underlie this phenomenon.
Leonid Visochek +14 more
openalex +4 more sources
Sos2 is dispensable for NMDA-induced Erk activation and LTP induction [PDF]
Neuroscience Letters, 2009 N-methyl-d-aspartate (NMDA) receptor-induced activation of extracellular signal-related protein kinase (Erk) plays important roles in various neuronal functions including long-term potentiation (LTP). Son of sevenless (Sos) proteins have been implicated in NMDA-induced Erk activation in neurons of young mice.
Junko Arai, Shaomin Li, Larry A. Feig
openalex +3 more sources
Scientific Reports, 2023 Activation of β-adrenergic receptors (β-ARs) not only enhances learning and memory but also facilitates the induction of long-term potentiation (LTP), a form of synaptic plasticity involved in memory formation.
Shekib A. Jami +7 more
doaj +1 more source
LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia. [PDF]
Neuron, 2020 Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic glutamate actions is ...
Henneberger C +22 more
europepmc +8 more sources