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Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP
Science, 1988The contributions of two subclasses of excitatory amino acid transmitter receptors to the induction and expression of long-term potentiation (LTP) were analyzed in hippocampal slices. The quisqualate/kainate receptor antagonist DNQX (6,7-dinitroquinoxaline-2,3-dione) blocked 85% of the evoked field potential, leaving a small response that ...
Gary Lynch +2 more
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Presynaptic induction and expression of NMDA-dependent LTP
Trends in Neurosciences, 2004It is almost axiomatic in neuroscience that postsynaptically induced NMDA-dependent long-term potentiation (LTP) is a cellular substrate of memory. As a result, memory impairments caused by experimental reductions of NMDA currents are often interpreted as evidence that this form of plasticity is involved in memory formation.
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Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
Science, 1994Repeated high-frequency trains of stimuli induce long-term potentiation (LTP) in the CA1 region that persists for up to 8 hours in hippocampal slices and for days in intact animals. This long time course has made LTP an attractive model for certain forms of long-term memory in the mammalian brain.
Ted Abel +2 more
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Parameters of LTP Induction Modulate Network Categorization Behavior [PDF]
, 1997 Long-term potentiation (LTP) can only be induced at a synapse up to a fixed maximum extent; the magnitude of this ceiling has been found to be modulated by both endogenous and exogenous factors. The effect of the LTP ceiling on network-level categorization performance in a simulated layer of cortical neurons is investigated. The simulation is presented
Don Kubota +3 more
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Requirements for LTP Induction by Pairing in Hippocampal CA1 Pyramidal Cells
Journal of Neurophysiology, 1999The induction of long-term potentiation (LTP) in the hippocampal CA1 region requires both presynaptic activity and large postsynaptic depolarization. A standard protocol for inducing LTP using whole-cell recording is to pair low-frequency synaptic stimulation (100–200 pulses, 1–2 Hz) with a depolarizing voltage-clamp pulse (1–3 min duration).
John E. Lisman +2 more
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Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP
Science, 1989Long-term potentiation (LTP) of synaptic transmission is a widely studied cellular example of synaptic plasticity. However, the identity, localization, and interplay among the biochemical signals underlying LTP remain unclear. Intracellular microelectrodes have been used to record synaptic potentials and deliver protein kinase inhibitors ...
Richard W. Tsien +2 more
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Dopaminergic modulation of LTP induction in the dentate gyrus of intact brain
NeuroReport, 1997The effect of the dopamine system on the induction of long-term potentiation (LTP) in the dentate gyrus was studied in anesthetized rats. A subthreshold tetanic train (seven pulses at 100 Hz) given to the perforant pathway, which usually fails to elicit LTP, potentiated a slope of field excitatory postsynaptic potentiation (fEPSP) measured from the ...
Satoshi Ueda +3 more
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LTD induction suppresses LTP-induced hippocampal adult neurogenesis
NeuroReport, 2009Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis.
Chun, SK Chun, Sung Kun +2 more
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Induction of LTP in rat primary visual cortex: tetanus parameters
Brain Research, 1989Long-term potentiation (LTP), intensively studied in the hippocampus as a possible mnemonic device, has begun to be studied in the neocortex. In this study the effects of varying tetanic stimulus parameters on LTP of field potentials recorded from layer II/III induced by white matter stimulation in the in vitro rat visual cortical slice were examined ...
Timothy J. Teyler +2 more
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Acute and chronic nicotine exposure differentially facilitate the induction of LTP
Brain Research, 1999We report here that acute and chronic nicotine exposure facilitated the induction of long-term potentiation (LTP), a leading candidate for a cellular mechanism underlying learning and memory, in the hippocampus. Furthermore, acute application of nicotine in chronic nicotine-treated hippocampus further facilitated the induction of LTP, suggesting that ...
Satoshi Fujii +3 more
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