Results 261 to 270 of about 1,151,700 (338)

Changes in the cortical GABAergic inhibitory system with ageing and ageing‐related neurodegenerative diseases

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend With ageing and age‐related neurodegenerative diseases, the amount of GABA and GABAergic inhibition as well as the modulation (indicated by sine wave) of GABAergic inhibition is reduced, whereas excitation is increased. In many parts of the brain, this leads to a mismatch of facilitatory (green neurons) and inhibitory (red ...
Wolfgang Taube, Benedikt Lauber
wiley   +1 more source

Activity‐induced conversion from dendritic filopodia to spines mediated by NMDA receptor‐dependent calcium transients and vesicular exocytosis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram of the conversion of dendritic filopodium into spine. Inactivation‐induced filopodia contain NMDA receptors along with recycling endosomes and microtubules. Glycine stimulation facilitates the occurrence of calcium influx through NMDA receptors, causing exocytosis of recycling endosomes via a VAMP‐dependent ...
Hui‐Jing Liu   +5 more
wiley   +1 more source

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak   +35 more
wiley   +1 more source

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos   +3 more
wiley   +1 more source

Enhanced cycling of presynaptic vesicles during long‐term potentiation in rat hippocampus

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Illustration of the sequence of events leading to the sustained enhancement of presynaptic vesicle cycling during long‐term potentiation (LTP). At time 0, all presynaptic axonal boutons contain a pool of non‐docked vesicles and docked synaptic vesicles tethered to the presynaptic active zone.
Kristen M. Harris
wiley   +1 more source

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