Results 271 to 280 of about 47,591 (317)

Activity-dependent extracellular proteolytic cascade cleaves the ECM component brevican to promote structural plasticity. [PDF]

EMBO Rep
Singh JB, Perelló-Amorós B, Schneeberg J, Mirzapourdelavar H, Seidenbecher CI, Fejtová A, Dityatev A, Frischknecht R.   +7 more
europepmc   +1 more source

Engineering an Anaerobic Microenvironment to Empower Hydrogenase‐Catalyzed Hydrogen Therapy for Diabetic Wound Healing

Aggregate, Volume 7, Issue 2, February 2026.
A smart peptide hydrogel integrated with light‐responsive silver nanoclusters establishes a localized anaerobic niche, enabling hydrogenase function in oxygen‐rich biological environments. The system achieves sustained visible‐light‐driven H2 production, effectively scavenges reactive oxygen species, modulates immune responses, and significantly ...
Haishuo Ji, Yaling Wang, Kexin Yao, Junjie Li, Hang Luo, Wangzhe Li, Yanxin Gao, Wenjin Li, Qi Xiao, Tin Pou Lai, Chunxiao Chen, Xueying Li, Qian Peng, Chunqiu Zhang, Baofa Sun, Liyun Zhang   +15 more
wiley   +1 more source

Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis. [PDF]

Mol Brain
Miyake R, Yamanaka M, Taniguchi W, Nishio N, Matsuyama Y, Ueno T, Kaimochi Y, Nakatsuka T, Yamada H.   +8 more
europepmc   +1 more source

Spatial heterogeneity in microglia‐complement crosstalk: Implications for synaptic pruning in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye, Wei Gao, Jiaping Feng, Xue Li, Jianhui Li, Fengge Yang, Linqing Li, Mingsheng Zi, Xinkai Wu, Hainan Gao, Honglin Li   +10 more
wiley   +1 more source

Molecular Physiology of the Neuronal Synapse. [PDF]

Curr Issues Mol Biol
Ramírez-Expósito MJ, Cueto-Ureña C, Martínez-Martos JM.   +2 more
europepmc   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Long-term potentiation and long-term depression are both impaired after<i>in vitro</i>stretch injury measured with stretchable microelectrode arrays. [PDF]

Biomed Phys Eng Express
Dwyer MKR, Polsfuss I, Herbert K, Varghese N, Morrison B.   +4 more
europepmc   +1 more source

Efficacy of Repetitive Transcranial Magnetic Stimulation on Postoperative Delirium in Elderly Patients Undergoing Non‐Cardiac Major Surgery: A Randomized Controlled Trial

Brain and Behavior, Volume 16, Issue 2, February 2026.
In this double‐blind randomized controlled trial, preoperative 10‐Hz rTMS targeting the left DLPFC reduced postoperative delirium within 7 days in older adults undergoing elective non‐cardiac surgery compared with sham stimulation and was well tolerated.
Wen‐Bo Gao, Wen‐Hui Wang, Si‐Tong Zhou, Zi‐Wei Lu, Xin Xiang, Jin Hu, Ting‐Yu Jin, Chao‐Bo Ni, Ming Yao, Hua‐Dong Ni   +9 more
wiley   +1 more source

Incubation with tau aggregates increases hippocampal circuit excitability and enhances long-term depression in acute mouse hippocampal slices. [PDF]

Front Neural Circuits
Wang A, Richardson A, Emmett I, Friedmann D, Bakker S, Richardson M, Hill E, Wall M.   +7 more
europepmc   +1 more source

Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
UL induced significant spatial and non‐spatial cognitive dysfunction and hippocampal neurogenesis inhibition, whereas aerobic exercise intervention effectively reversed these impairments. Transcriptomic profiling and pharmacological evidence identified MHC class I/II–related pathways (H2‐K1, H2‐Eb1, CD74) as key mediators of the restorative effects of ...
Zhanghong Zhou, Xixi Yu, E. Tian, Zhaoqi Guo, Jingyu Chen, Jiaqi Guo, Shiyu Shi, Wandi Xu, Ni Zhai, Caijuan Qiao, Yuejin Zhang, Jun Wang, Yisheng Lu, Sulin Zhang   +13 more
wiley   +1 more source