Results 21 to 30 of about 22,985 (275)
Spine formation pattern of adult-born neurons is differentially modulated by the induction timing and location of hippocampal plasticity. [PDF]
PLoS ONE, 2012 In the adult hippocampus dentate gyrus (DG), newly born neurons are functionally integrated into existing circuits and play important roles in hippocampus-dependent memory.
Noriaki Ohkawa +8 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus.
Dongyang Cui +11 more
doaj +1 more source
Olfactory learning-induced enhancement of the predisposition for LTP induction [PDF]
Learning & Memory, 2011 Learning of a particularly difficult olfactory-discrimination (OD) task results in acquisition of rule learning. This enhancement in learning capability is accompanied by the long-term enhancement of synaptic connectivity between piriform cortex pyramidal neurons. In this study we examined whether olfactory rule learning would modify the predisposition
Yaniv Cohen +3 more
openalex +3 more sources
Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development. [PDF]
PLoS ONE, 2012 Current thinking about LTP triggered in the area CA1 of hippocampal slices is ruled by two "dogmas": (1) A single train of high-frequency stimulation is sufficient to trigger short-lasting LTP (1-3 h), whereas multiple trains are required to induce long ...
Agnès Villers +2 more
doaj +1 more source
An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction. [PDF]
Front Mol Neurosci, 2018 The small GTPase Rac1 promotes actin polymerization and plays a critical and increasingly appreciated role in the development and plasticity of glutamatergic synapses. Growing evidence suggests that disruption of the Rac1 signaling pathway at glutamatergic synapses contributes to Autism Spectrum Disorder/intellectual disability (ASD/ID)-related ...
Tian C +5 more
europepmc +6 more sources
Molecular Brain, 2022 Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs) and provide feedback control of synaptic inputs onto PC dendrites.
Ève Honoré +3 more
doaj +1 more source
BMC Neuroscience, 2023 Background The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) is augmented in cannabinoid type 1
Masoumeh Nazari +4 more
doaj +1 more source
Heliyon, 2017 Long-term potentiation (LTP) of synaptic transmission in the central nervous system is a key form of cortical plasticity. The insular cortex (IC) is known to play important roles in pain perception, aversive memory and mood disorders.
Manabu Yamanaka +3 more
doaj +1 more source
Acta Epileptologica, 2021 Background Cognitive impairment is one of the common comorbidities in patients with temporal lobe epilepsy (TLE), but the underlying mechanisms remain largely unknown.
Xiaoqing Luo +5 more
doaj +1 more source
Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]
PLoS Computational Biology, 2010 Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim +3 more
doaj +1 more source