Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. [PDF]
PLoS ONE, 2011 Fear memory formation is thought to require dopamine, brain-derived neurotrophic factor (BDNF) and zinc release in the basolateral amygdala (BLA), as well as the induction of long term potentiation (LTP) in BLA principal neurons.
Chenchen Li +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus.
Dongyang Cui +11 more
doaj +1 more source
Spine formation pattern of adult-born neurons is differentially modulated by the induction timing and location of hippocampal plasticity. [PDF]
PLoS ONE, 2012 In the adult hippocampus dentate gyrus (DG), newly born neurons are functionally integrated into existing circuits and play important roles in hippocampus-dependent memory.
Noriaki Ohkawa +8 more
doaj +1 more source
LTP induction modifies functional relationship among hippocampal neurons [PDF]
Learning & Memory, 2007 To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered ‘functional connectivity,’ as defined by the degree of synchronous firing, among ...
Yun, SH +5 more
openaire +3 more sources
Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development. [PDF]
PLoS ONE, 2012 Current thinking about LTP triggered in the area CA1 of hippocampal slices is ruled by two "dogmas": (1) A single train of high-frequency stimulation is sufficient to trigger short-lasting LTP (1-3 h), whereas multiple trains are required to induce long ...
Agnès Villers +2 more
doaj +1 more source
Molecular Brain, 2022 Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs) and provide feedback control of synaptic inputs onto PC dendrites.
Ève Honoré +3 more
doaj +1 more source
BMC Neuroscience, 2023 Background The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) is augmented in cannabinoid type 1
Masoumeh Nazari +4 more
doaj +1 more source
The Cdk5 Inhibitor Roscovitine Increases LTP Induction in Corticostriatal Synapses [PDF]
ASN Neuro, 2014 In corticostriatal synapses, LTD (long-term depression) and LTP (long-term potentiation) are modulated by the activation of DA (dopamine) receptors, with LTD being the most common type of long-term plasticity induced using the standard stimulation protocols.
Jorge Miranda-Barrientos +2 more
openaire +3 more sources
Acta Epileptologica, 2021 Background Cognitive impairment is one of the common comorbidities in patients with temporal lobe epilepsy (TLE), but the underlying mechanisms remain largely unknown.
Xiaoqing Luo +5 more
doaj +1 more source
Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]
, 2016 The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni +5 more
core +1 more source