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A developmental switch in the signaling cascades for LTP induction [PDF]

Nature Neuroscience, 2003
Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown.
H. Yasuda, Alison L. Barth, D. Stellwagen, R. Malenka   +3 more
semanticscholar   +3 more sources

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The role of extrasynaptic NMDARs in LTP induction

Neuroscience Research, 2010
Sheng-tian Li, Qian Yang, Jue-gang Ju, Yi-Xin Xiao, Yue Zhang, Gong Ju   +5 more
semanticscholar   +3 more sources

Coactivation of metabotropic and NMDA receptors is required for LTP induction.

NeuroReport, 1993
Induction of long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is dependent on N-methyl-D-aspartate (NMDA) receptor activation. However, NMDA receptor stimulation alone is not adequate to trigger LTP. Results from the present study indicate that, in addition to NMDA receptors, there is a requirement for co ...
M. A. Musgrave, B. Ballyk, Joanne W. Goh
semanticscholar   +4 more sources

Dopaminergic modulation of LTP induction in the dentate gyrus of intact brain

NeuroReport, 1997
The effect of the dopamine system on the induction of long-term potentiation (LTP) in the dentate gyrus was studied in anesthetized rats. A subthreshold tetanic train (seven pulses at 100 Hz) given to the perforant pathway, which usually fails to elicit LTP, potentiated a slope of field excitatory postsynaptic potentiation (fEPSP) measured from the ...
T. Kusuki, Y. Imahori, S. Ueda, K. Inokuchi   +3 more
semanticscholar   +4 more sources

Endocannabinoids facilitate the induction of LTP in the hippocampus

Nature Neuroscience, 2002
Exogenous cannabinoids disrupt behavioral learning and impede induction of long-term potentiation (LTP) in the hippocampus, yet endogenous cannabinoids (endocannabinoids) transiently suppress inhibitory post-synaptic currents (IPSCs) by activating cannabinoid CB1 receptors on GABAergic interneurons.
Gregory C. Carlson, Bradley E. Alger, Yue Wang   +2 more
openaire   +3 more sources

GABAB autoreceptors regulate the induction of LTP

Nature, 1991
Understanding the mechanisms involved in long-term potentiation (LTP) should provide insights into the cellular and molecular basis of learning and memory in vertebrates. It has been established that in the CA1 region of the hippocampus the induction of LTP requires the transient activation of the N-methyl-D-aspartate (NMDA) receptor system. During low-
Graham L. Collingridge, Graham L. Collingridge, Sarah J. Starkey, Sarah J. Starkey, Mario F. Pozza, Mario F. Pozza, Ceri H. Davies, Ceri H. Davies   +7 more
openaire   +3 more sources

Requirements for LTP induction by pairing in hippocampal CA1 pyramidal cells.

Journal of Neurophysiology, 1999
The induction of long-term potentiation (LTP) in the hippocampal CA1 region requires both presynaptic activity and large postsynaptic depolarization. A standard protocol for inducing LTP using whole-cell recording is to pair low-frequency synaptic stimulation (100–200 pulses, 1–2 Hz) with a depolarizing voltage-clamp pulse (1–3 min duration).
Huan-Xin Chen, N. Otmakhov, John E. Lisman   +2 more
semanticscholar   +4 more sources

Evidence that matrix recognition contributes to stabilization but not induction of LTP

NeuroReport, 1991
Slices of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, they did produce a reversible, dose ...
Ben A. Bahr, Peng Xiao, Peter W. Vanderklish, Ursula Staubli, Gary Lynch   +4 more
openaire   +3 more sources

Nicotine primes the effect of cocaine on the induction of LTP in the amygdala

Neuropharmacology, 2013
In human populations, there is a well-defined sequence of involvement in drugs of abuse, in which the use of nicotine or alcohol precedes the use of marijuana, which in turn, precedes the use of cocaine. The term "Gateway Hypothesis" describes this developmental sequence of drug involvement.
Amir Levine, Yan-You Huang, Denise B. Kandel, Eric R. Kandel   +3 more
openaire   +2 more sources