Results 301 to 310 of about 47,591 (317)

Parameters of LTP Induction Modulate Network Categorization Behavior

1997
Long-term potentiation (LTP) can only be induced at a synapse up to a fixed maximum extent; the magnitude of this ceiling has been found to be modulated by both endogenous and exogenous factors. The effect of the LTP ceiling on network-level categorization performance in a simulated layer of cortical neurons is investigated. The simulation is presented
Karl Kilborn, Don Kubota, Gary Lynch, Richard Granger   +3 more
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Requirements for LTP Induction by Pairing in Hippocampal CA1 Pyramidal Cells

Journal of Neurophysiology, 1999
The induction of long-term potentiation (LTP) in the hippocampal CA1 region requires both presynaptic activity and large postsynaptic depolarization. A standard protocol for inducing LTP using whole-cell recording is to pair low-frequency synaptic stimulation (100–200 pulses, 1–2 Hz) with a depolarizing voltage-clamp pulse (1–3 min duration).
H X, Chen, N, Otmakhov, J, Lisman
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Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction

Journal of Medicinal Chemistry, 2015
Acid sensing ion channels 1a (ASIC1a) are of crucial importance in numerous physiological and pathological processes in the brain. Here we demonstrate that novel 2-oxo-2H-chromene-3-carboxamidine derivative 5b, designed with molecular modeling approach, inhibits ASIC1a currents with an apparent IC50 of 27 nM when measured at pH 6.7.
Buta A., Maximyuk O., Kovalskyy D., Sukach V., Vovk M., Ievglevskyi O., Isaeva E., Isaev D., Savotchenko A., Krishtal O.   +9 more
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Acute and chronic ethanol exposure differentially affect induction of hippocampal LTP

Brain Research, 2008
Using hippocampal slices, we found that chronic ethanol consumption by rats induces tolerance to the impairing effects of acute ethanol treatment on induction of long-term potentiation (LTP) in CA1 neurons. In hippocampal slices from pair-fed control rats, stable LTP was induced by tetanic stimulation consisting of 25 or more pulses at 100 Hz, but not ...
Satoshi, Fujii, Yoshihiko, Yamazaki, Toshimichi, Sugihara, Ichiro, Wakabayashi   +3 more
openaire   +2 more sources

Induction of LTP in the human auditory cortex by sensory stimulation

European Journal of Neuroscience, 2005
AbstractHigh‐frequency, repetitive, auditory stimulation was used to determine whether induction of a long‐lasting increase of the human auditory evoked potential (AEP) was possible. Recording non‐invasively with electroencephalogram scalp electrodes, stable increases in amplitude were observed in the N1 component of the AEP, which is thought to ...
W C, Clapp, I J, Kirk, J P, Hamm, D, Shepherd, T J, Teyler   +4 more
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Mechanisms of LTP Induction in Rat Motor Cortex in vitro

Cerebral Cortex, 1995
The motor cortex displays remarkable plasticity in response to changes in sensory and motor experience; however, the synaptic mechanisms underlying functional plasticity are not known. It is believed that synaptic processes that alter the strength of neuronal connections, such as long-term potentiation (LTP), are mechanisms by which synaptic circuits ...
V A, Aroniadou, A, Keller
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Evidence for Postsynaptic Induction and Expression of NMDA Receptor Independent LTP

Journal of Neurophysiology, 1998
Grover, Lawrence M. Evidence for postsynaptic induction and expression of NMDA receptor independent LTP. J. Neurophysiol. 79: 1167–1182, 1998. Whole cell/patch-clamp and extracellular field potential recordings were used to study the induction and expression of N-methyl-d-aspartate (NMDA) receptor independent long-term potentiation (LTP) in area CA1 of
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GTP-binding protein activation underlies LTP induction by Mast Cell Degranulating peptide

Neuroscience Research, 1996
Mast cell degranulating peptide (MCD) induces long-term potentiation (LTP) in the CA1 region of the hippocampus. MCD has been shown to bind to a voltage-dependent A-type potassium channel with high-affinity (less than 1 nM). However, the concentration necessary to induce LTP is more than 500 nM, suggesting that some other functions of MCD are also ...
I, Fujimoto, S, Oiki, T, Kondo, T, Katada, H, Kato, T, Taguchi, M, Kasai, Y, Okada, K, Mikoshiba, K, Ikenaka   +9 more
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Evidence that matrix recognition contributes to stabilization but not induction of LTP

NeuroReport, 1991
Slices of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, they did produce a reversible, dose ...
P, Xiao, B A, Bahr, U, Staubli, P W, Vanderklish, G, Lynch   +4 more
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Molecular mechanism underlying LTP-induction by MCD

Neuroscience Research Supplements, 1992
Ichiro Fujimoto, Kazuhiro Ikenaka, Tetsuro Kondo, Hiroshi Kato, Kenichi Ito, Katsuhiko Mikoshiba   +5 more
openaire   +1 more source