Heliyon, 2017 Long-term potentiation (LTP) of synaptic transmission in the central nervous system is a key form of cortical plasticity. The insular cortex (IC) is known to play important roles in pain perception, aversive memory and mood disorders.
Manabu Yamanaka +3 more
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Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]
PLoS Computational Biology, 2010 Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim +3 more
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Critical Differences in Magnitude and Duration of N-methyl-D-aspartate (NMDA) Receptor Activation between Long-term Potentiation (LTP) and Long-term Depression (LTD) Induction [PDF]
, 2008 The induction of both long-term potentiation (LTP) and long-term depression (LTD) in the hippocampal CA1 region is triggered by the activation of N-methyl-D-aspartate (NMDA) receptors and the subsequent postsynaptic intracellular Ca2+ increase.
Lu, Yun-Fei +3 more
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Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination [PDF]
Journal of Neurochemistry, 2001 Hippocampal long‐term potentiation (LTP) is a robust and long‐lasting form of synaptic plasticity that is the leading candidate for a cellular mechanism contributing to mammalian learning and memory. Investigations over the past decade have revealed that the biochemistry of LTP induction involves mechanisms of great subtlety and complexity. This review
Kelly T. Dineley +5 more
openalex +3 more sources
Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons: Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors [PDF]
, 2015 An anti-Hebbian form of LTP is observed at excitatory synapses made with some hippocampal interneurons. LTP induction is facilitated when postsynaptic interneurons are hyperpolarized, presumably because Ca(2+) entry through Ca(2+)-permeable glutamate ...
Kullmann, DM +3 more
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Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the Hippocampus
Frontiers in Cellular Neuroscience, 2013 Disinhibition-mediated long-term potentiation (LTP) in the CA1 region of the hippocampus involves GABAergic synaptic plasticity at feedforward inhibitory inputs, resulting in the reduced shunting of glutamatergic excitatory currents.
Petri eTakkala, Melanie A Woodin
doaj +1 more source
Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation [PDF]
, 2011 Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons.
Izumi, Yukitoshi +2 more
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PLoS ONE, 2010 BackgroundLong-term potentiation (LTP) at the parallel fibre-Purkinje cell synapse in the cerebellum is a recently described and poorly characterized form of synaptic plasticity. The induction mechanism for LTP at this synapse is considered reciprocal to
Claire Jackson +2 more
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Synaptic memory requires CaMKII
eLife, 2021 Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the maintenance of LTP (‘memory’) has remained contentious over ...
Wucheng Tao +6 more
doaj +1 more source
Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation [PDF]
, 2010 Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting ~3 h (called early-LTP) will maintain a longer-lasting change in efficacy (late-LTP) if the weak tetanization occurs shortly before or after ...
Bito, Haruhiko +5 more
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