Results 31 to 40 of about 22,985 (275)
Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the Hippocampus
Frontiers in Cellular Neuroscience, 2013 Disinhibition-mediated long-term potentiation (LTP) in the CA1 region of the hippocampus involves GABAergic synaptic plasticity at feedforward inhibitory inputs, resulting in the reduced shunting of glutamatergic excitatory currents.
Petri eTakkala, Melanie A Woodin
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On the Induction of Postsynaptic Granule Cell–Purkinje Neuron LTP and LTD [PDF]
The Cerebellum, 2010 In the last decade, several experimental studies have demonstrated that particular patterns of synaptic activity can induce postsynaptic parallel fiber (PF) long-term potentiation (LTP). This form of plasticity can reverse postsynaptic PF long-term depression (LTD), which has been traditionally considered as the principal form of plasticity underlying ...
Kaspar E. Vogt +2 more
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PLoS ONE, 2010 BackgroundLong-term potentiation (LTP) at the parallel fibre-Purkinje cell synapse in the cerebellum is a recently described and poorly characterized form of synaptic plasticity. The induction mechanism for LTP at this synapse is considered reciprocal to
Claire Jackson +2 more
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The Cdk5 inhibitor Roscovitine increases LTP induction in corticostriatal synapses. [PDF]
ASN Neuro, 2014 In corticostriatal synapses, LTD (long-term depression) and LTP (long-term potentiation) are modulated by the activation of DA (dopamine) receptors, with LTD being the most common type of long-term plasticity induced using the standard stimulation protocols.
Miranda-Barrientos J +2 more
europepmc +6 more sources
Synaptic memory requires CaMKII
eLife, 2021 Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the maintenance of LTP (‘memory’) has remained contentious over ...
Wucheng Tao +6 more
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Properties of LTP induction in the CA3 region of the primate hippocampus. [PDF]
Learning & Memory, 1996 Activity-dependent changes in synaptic strength, such as long-term potentiation (LTP), have been proposed to underlie memory storage in the brains of all mammals, including humans. However, most forms of synaptic plasticity, including LTP, are studied almost exclusively in rodents and related species. Thus, the hypothesis that LTP is important in human
David A. Lewis +3 more
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Postsynaptic Induction and PKA-Dependent Expression of LTP in the Lateral Amygdala [PDF]
Neuron, 1998 Whereas much is now known about the behavioral importance of the lateral nucleus of the amygdala for the storage of implicit memories of fear, little is known in molecular terms about the signal transduction pathways required for long-term potentiation (LTP) in this nucleus. Using brain slices containing the amygdala, we have studied LTP in the pathway
Yan-You Huang, Eric R. Kandel
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What does LTP tell us about the roles of CaMKII and PKMζ in memory?
Molecular Brain, 2018 In “Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ),” Lisman proposes that elucidating the mechanism of LTP maintenance is key to understanding memory storage.
Todd Charlton Sacktor +1 more
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iScience, 2023 Summary: The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is crucial for translation and regulated by Ser209 phosphorylation. However, the biochemical and physiological role of eIF4E phosphorylation in translational control of long ...
Sudarshan Patil +7 more
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Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy
Molecular Pain, 2011 Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with hyperalgesia and has been proposed to be a cellular mechanism of pain amplification in acute and chronic pain states.
Liu Xian-Guo +4 more
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