Heliyon, 2017 Long-term potentiation (LTP) of synaptic transmission in the central nervous system is a key form of cortical plasticity. The insular cortex (IC) is known to play important roles in pain perception, aversive memory and mood disorders.
Manabu Yamanaka +3 more
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Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]
PLoS Computational Biology, 2010 Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim +3 more
doaj +1 more source
Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons: Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors [PDF]
, 2015 An anti-Hebbian form of LTP is observed at excitatory synapses made with some hippocampal interneurons. LTP induction is facilitated when postsynaptic interneurons are hyperpolarized, presumably because Ca(2+) entry through Ca(2+)-permeable glutamate ...
Kullmann, DM +3 more
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Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the Hippocampus
Frontiers in Cellular Neuroscience, 2013 Disinhibition-mediated long-term potentiation (LTP) in the CA1 region of the hippocampus involves GABAergic synaptic plasticity at feedforward inhibitory inputs, resulting in the reduced shunting of glutamatergic excitatory currents.
Petri eTakkala, Melanie A Woodin
doaj +1 more source
Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation [PDF]
, 2011 Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons.
Izumi, Yukitoshi +2 more
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The Cdk5 inhibitor Roscovitine increases LTP induction in corticostriatal synapses. [PDF]
ASN Neuro, 2014 In corticostriatal synapses, LTD (long-term depression) and LTP (long-term potentiation) are modulated by the activation of DA (dopamine) receptors, with LTD being the most common type of long-term plasticity induced using the standard stimulation protocols.
Miranda-Barrientos J +2 more
europepmc +6 more sources
PLoS ONE, 2010 BackgroundLong-term potentiation (LTP) at the parallel fibre-Purkinje cell synapse in the cerebellum is a recently described and poorly characterized form of synaptic plasticity. The induction mechanism for LTP at this synapse is considered reciprocal to
Claire Jackson +2 more
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Synaptic memory requires CaMKII
eLife, 2021 Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the maintenance of LTP (‘memory’) has remained contentious over ...
Wucheng Tao +6 more
doaj +1 more source
On the Induction of Postsynaptic Granule Cell–Purkinje Neuron LTP and LTD [PDF]
The Cerebellum, 2010 In the last decade, several experimental studies have demonstrated that particular patterns of synaptic activity can induce postsynaptic parallel fiber (PF) long-term potentiation (LTP). This form of plasticity can reverse postsynaptic PF long-term depression (LTD), which has been traditionally considered as the principal form of plasticity underlying ...
Kaspar E. Vogt +2 more
openaire +4 more sources
Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells [PDF]
, 2010 Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP).
Belmeguenai, Amor +14 more
core +3 more sources