Results 41 to 50 of about 47,591 (317)

Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells [PDF]

, 2010
Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP).
Belmeguenai, Amor, Bengtsson, Fredrik,, De Jeu, Marcel T. G., De Zeeuw, Chris I., Elgersma, Ype, Hansel, Christian, He, Qionger, Hosy, Eric, Jörntell, Henrik,, Lund University., Lund University., Ohtsuki, Gen, Pedroarena, Christine M., Piochon, Claire, Teuling, Eva   +14 more
core   +4 more sources

Interactions between short-term and long-term plasticity: shooting for a moving target [PDF]

, 2011
Far from being static transmission units, synapses are highly dynamical elements that change over multiple time scales depending on the history of the neural activity of both the pre- and postsynaptic neuron.
Jean-Pascal Pfister, Má
core   +2 more sources

Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy

Molecular Pain, 2011
Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with hyperalgesia and has been proposed to be a cellular mechanism of pain amplification in acute and chronic pain states.
Liu Xian-Guo, Drdla Ruth, Wilder-Smith Oliver, Ruscheweyh Ruth, Sandkühler Jürgen   +4 more
doaj   +1 more source

Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model. [PDF]

PLoS Computational Biology, 2012
Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plasticity.
Paul Smolen, Douglas A Baxter, John H Byrne   +2 more
doaj   +1 more source

eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance

iScience, 2023
Summary: The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is crucial for translation and regulated by Ser209 phosphorylation. However, the biochemical and physiological role of eIF4E phosphorylation in translational control of long ...
Sudarshan Patil, Kleanthi Chalkiadaki, Tadiwos F. Mergiya, Konstanze Krimbacher, Inês S. Amorim, Shreeram Akerkar, Christos G. Gkogkas, Clive R. Bramham   +7 more
doaj   +1 more source

State based model of long-term potentiation and synaptic tagging and capture [PDF]

, 2009
Recent data indicate that plasticity protocols have not only synapse-specific but also more widespread effects. In particular, in synaptic tagging and capture (STC), tagged synapses can capture plasticity-related proteins, synthesized in response to ...
A Govindarajan, A Hayer, AB Barrett, Adam B. Barrett, AJ Heynen, AM Zhabotinsky, B Hille, CCH Petersen, CM O'Carroll, D Amit, DH O'Connor, EM Izhikevich, Guy O. Billings, H Okamoto, HK Lee, HZ Shouval, HZ Shouval, JE Lisman, JR Whitlock, JW Lin, KG Reymann, Lyle J. Graham, M Graupner, M Krug, Mark C. W. van Rossum, NH Woo, P Miller, P Smolen, R Fonseca, R Fonseca, R Fonseca, Richard G. M. Morris, S Li, S Sajikumar, S Sajikumar, S Sajikumar, S Sajikumar, S Sajikumar, SJ Martin, SM Dudek, T Dunwiddie, U Frey, U Frey, U Frey, U Frey, U Staubli, W Senn, WC Abraham, WC Abraham, WS Sossin, Y Yao   +50 more
core   +5 more sources

LTP induction boosts glutamate spillover by driving withdrawal of astroglia [PDF]

SSRN Electronic Journal, 2018
SUMMARYExtrasynaptic actions of glutamate are limited by high-affinity transporters on perisynaptic astroglial processes (PAPs), which helps to maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodelling, but how this remodelling affects PAPs and therefore extrasynaptic glutamate ...
Henneberger, Christian, Bard, Lucie, Panatier, Aude, Reynolds, James P., Kopach, Olga, Medvedev, Nikolay I., Minge, Daniel, Herde, Michel K., Anders, Stefanie, Kraev, Igor, Heller, Janosch P., Rama, Sylvain, Zheng, Kaiyu, Jensen, Thomas P., Sanchez-Romero, Inmaculada, Jackson, Colin, Janovjak, Harald, Ottersen, Ole Petter, Nagelhus, Erlend Arnulf, Oliet, Stephane H.R., Stewart, Michael G., Nägerl, U. Valentin, Rusakov, Dmitri A.   +22 more
openaire   +1 more source

What does LTP tell us about the roles of CaMKII and PKMζ in memory?

Molecular Brain, 2018
In “Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ),” Lisman proposes that elucidating the mechanism of LTP maintenance is key to understanding memory storage.
Todd Charlton Sacktor, André Antonio Fenton   +1 more
doaj   +1 more source

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]

, 2008
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel, Arendt, Atack, Bain, Bear, Blanquet, Bliss, Blitzer, Blitzer, Bogan, Casey, Charpantier, Cho, Dajas-Bailador, Davies, Davis, Decker, Dhavan, Dominguez del Toro, English, Faghih, Fujii, Giovannini, Gray, Hope, Huang, Huang, Hunter, Hurst, Ji, Jones, Kawakami, Kelly, Kihara, Klein, Krause, Le Novere, Levin, Li, Liston, Lu, Man, Mann, Marrero, Matsuyama, Matthies, Meriane, Opazo, O’Dell, Peavy, Picciotto, Polesskaya, Polesskaya, Radcliffe, Roberson, Rush, Salazar, Sanna, Sanna, Santos, Seguela, Sharifzadeh, Sharifzadeh, Sharma, Shaw, Shaw, Sweatt, Takada-Takatori, Tominaga-Yoshino, Wada, Wang, Wang, Welsby, Welsby, Whitehouse, Woo, Wu, Yang, Ying, Yu, Zhang, Zwart   +81 more
core   +1 more source

Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex

Molecular Pain, 2007
Long-term potentiation (LTP) in the anterior cingulate cortex (ACC) is believed to be critical for higher brain functions including emotion, learning, memory and chronic pain.
Ren Ming, Wu Long-Jun, Xu Hui, Zhao Ming-Gao, Toyoda Hiroki, Zhuo Min   +5 more
doaj   +1 more source