Results 41 to 50 of about 22,985 (275)

Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model. [PDF]

PLoS Computational Biology, 2012
Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plasticity.
Paul Smolen, Douglas A Baxter, John H Byrne   +2 more
doaj   +1 more source

Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex

Molecular Pain, 2007
Long-term potentiation (LTP) in the anterior cingulate cortex (ACC) is believed to be critical for higher brain functions including emotion, learning, memory and chronic pain.
Ren Ming, Wu Long-Jun, Xu Hui, Zhao Ming-Gao, Toyoda Hiroki, Zhuo Min   +5 more
doaj   +1 more source

Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus. [PDF]

PLoS ONE, 2012
Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit both small conductance Ca(2+)-activated KCa2 ...
Milos M Petrovic, Jakub Nowacki, Valeria Olivo, Krasimira Tsaneva-Atanasova, Andrew D Randall, Jack R Mellor   +5 more
doaj   +1 more source

Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses

Cell Reports, 2018
Summary: Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), regulate long-term potentiation (LTP) in the hippocampus, although the sites of BDNF-TrkB receptors in this process are controversial.
Pei-Yi Lin, Ege T. Kavalali, Lisa M. Monteggia   +2 more
doaj   +1 more source

The CaMKII/NMDAR complex as a molecular memory

Molecular Brain, 2013
CaMKII is a major synaptic protein that is activated during the induction of long-term potentiation (LTP) by the Ca2+ influx through NMDARs. This activation is required for LTP induction, but the role of the kinase in the maintenance of LTP is less clear.
Sanhueza Magdalena, Lisman John
doaj   +1 more source

Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo.

PLoS ONE, 2012
Long-term potentiation (LTP) is widely accepted as a cellular mechanism underlying memory processes. It is well established that LTP persistence is strongly dependent on activation of constitutive and inducible transcription factors, but there is limited
Margaret M Ryan, Brigid Ryan, Madeleine Kyrke-Smith, Barbara Logan, Warren P Tate, Wickliffe C Abraham, Joanna M Williams   +6 more
doaj   +1 more source

Orexin and cannabinoid systems modulate long-term potentiation of the hippocampus CA1 area in anesthetized rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Long-term potentiation (LTP) is a kind of synaptic plasticity and has a key role in learning and memory. Endocannabinoids and orexins are the endogenous systems that can modulate synaptic plasticity.
Reza Fartootzadeh, Ramezan Taheri, Mohammad Reza Nourani, Kamelya Goudarzi   +3 more
doaj   +1 more source

Mimicking Synaptic Plasticity: Optoionic MoS2 Memory Powered by Biopolymer Hydrogels as a Dynamic Cations Reservoir

Advanced Functional Materials, EarlyView.
Janus (MoS2) transistors functionalized with sodium alginate (SA) and poly(vinylidene fluoride‐co‐trifluoroethylene) [P(VDF‐TrFE)] exhibit persistent photo‐induced ionic gating, driven by dynamic cation migration at the hybrid interface. This ionic mechanism enables finely tunable photoconductivity and emulates key synaptic plasticity behaviors ...
Yeonsu Jeong, Pietro Tordi, Adrián Tamayo, Bin Han, Massimo Bonini, Paolo Samorì   +5 more
wiley   +1 more source

Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.

PLoS ONE, 2013
The hippocampus receives dopaminergic projections from the ventral tegmental area (VTA). Modulatory effect of dopamine on hippocampal long term potentiation (LTP) has been studied before, but there are conflicting results and some limitations in previous
Elham Ghanbarian, Fereshteh Motamedi
doaj   +1 more source

Enhanced Switching Performance in Single‐Crystalline PbTiO3 Ferroelectric Memristors for Replicating Synaptic Plasticity

Advanced Functional Materials, EarlyView.
This study demonstrated single‐crystalline PbTiO3‐based memristors with atomically sharp interfaces, well‐ordered lattices, and minimal lattice mismatch. The devices exhibited an ON/OFF ratio exceeding 105, high stability, and rich resistance‐state modulation.
Haining Li, Zhiqiang Liao, Risa Kataoka, Md Sarker Shamim, Takeshi Kijima, Hiroyasu Yamahara, Hitoshi Tabata, Munetoshi Seki   +7 more
wiley   +1 more source