Results 101 to 110 of about 45,749 (264)
Advanced Science, EarlyView.A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.Cyclic adenosine monophosphate (cAMP) is a key cellular second messenger. Adenylyl cyclase converts emissive isomorphic nucleoside triphosphates into fluorescent cAMPs. cthAMP displays unusually high brightness compared to thATP, its precursor, enabling real‐time monitoring of enzymatic reactions.
Deyuan Cong +3 more
wiley +2 more sources
Advanced Science, EarlyView.Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Driven by sodium dithionite and hydrogen peroxide under mild aqueous conditions, a water‐soluble perylene bisimide undergoes reversible electron‐transfer cycles that generate its emissive excited state without dye decomposition. We define this out‐of‐equilibrium system as chemically fueled regenerative chemiluminescence (CFRCL), opening new avenues for
Luca Morgan +5 more
wiley +2 more sources
Advanced Science, EarlyView.A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang +8 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang +9 more
wiley +1 more source
Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity
Advanced Science, EarlyView.Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen +17 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li +15 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias +5 more
wiley +1 more source
A bioluminescent activity dependent platform, BLADe, for converting intracellular activity to photoreceptor activation. [PDF]
Sci RepCrespo EL +10 more
europepmc +1 more source