Results 31 to 40 of about 151,628 (269)

A Design of High-Efficiency: Vertical Accumulation Modulators Based on Silicon Photonics

Nanomaterials, 2023
On-chip optical modulators, which are capable of converting electrical signals into optical signals, constitute the foundational components of photonic devices.
Zhipeng Zhou, Zean Li, Cheng Qiu, Yongyi Chen, Yingshuai Xu, Xunyu Zhang, Yiman Qiao, Yubing Wang, Lei Liang, Yuxin Lei, Yue Song, Peng Jia, Yugang Zeng, Li Qin, Yongqiang Ning, Lijun Wang   +15 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A dual-descriptor machine learning framework for evaluating perovskite passivation materials [PDF]

RSC Advances
Molecular passivation plays a crucial role in improving the efficiency and stability of perovskite optoelectronic devices. However, quantitative evaluation of passivation materials remains challenging because interfacial binding strength and lattice ...
Yao Lu, Jie Dong, Juan Meng, Yaoyao Li, Jiao Wu, Ning Meng, Xiaomin Huo, Suling Zhao, Zheng Xu, Dandan Song   +9 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Active Region Mode Control for High-Power, Low-Linewidth Broadened Semiconductor Optical Amplifiers for Light Detection and Ranging

Sensors
This paper introduces a semiconductor optical amplifier (SOA) with high power and narrow linewidth broadening achieved through active region mode control. By integrating mode control with broad-spectrum epitaxial material design, the device achieves high
Hui Tang, Meng Zhang, Lei Liang, Tianyi Zhang, Li Qin, Yue Song, Yuxin Lei, Peng Jia, Yubing Wang, Cheng Qiu, Chuantao Zheng, Xin Li, Yongyi Chen, Dan Li, Yongqiang Ning, Lijun Wang   +15 more
doaj   +1 more source

A High-Precision Method for Dynamically Measuring Train Wheel Diameter Using Three Laser Displacement Transducers

Sensors, 2019
Wheel diameter is a significant geometric parameter related to the safe operation of trains, and needs to be measured dynamically. To the best of the authors’ knowledge, most existing dynamic measurement methods and systems do not meet the ...
Fajia Zheng, Bin Zhang, Run Gao, Qibo Feng   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Deep-Learning-Driven Image Reconstruction for Comprehensive Geometric Measurement of High-Aspect-Ratio Blind Holes

Photonics
Accurately measuring geometric parameters of high-aspect-ratio blind holes is a critical requirement for microelectronics and micro–nanooptics applications.
He Geng, Xinlong Chen, Pengxi Chen, Jiayue Xu, Danni Wang, Fajia Zheng, Qibo Feng   +6 more
doaj   +1 more source

Interferometric Wavefront Sensing System Based on Deep Learning

Applied Sciences, 2020
At present, most wavefront sensing methods analyze the wavefront aberration from light intensity images taken in dark environments. However, in general conditions, these methods are limited due to the interference of various external light sources.
Yuhao Niu, Zhan Gao, Chenjia Gao, Jieming Zhao, Xu Wang   +4 more
doaj   +1 more source