Results 51 to 60 of about 49,910 (293)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Basic characterization of antibodies targeting receptors of the tumor necrosis factor receptor superfamily

Frontiers in Immunology, 2023
Many new immunotherapeutic approaches aim on the stimulatory targeting of receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) using antibodies with intrinsic or conditional agonism.
Olena Zaitseva, Mohamed Anany, Mohamed Anany, Harald Wajant, Isabell Lang   +4 more
doaj   +1 more source

Pushing the Limits of Luminescence Thermometry: Probing the Temperature of Proteins in Cells [PDF]

Journal of Biological Physics, 2021
Proteins are involved in numerous cellular activities such as transport and catalysis. Misfolding during biosynthesis and malfunctioning as a molecular machine may lead to physiological disorders and metabolic problems. Protein folding and mechanical work may be viewed as thermodynamic energetically favorable processes in which stochastic ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Non-covalent Binding of Luminescent Transition Metal Polypyridine Complexes to Avidin, Iodole-binding Proteins and Estrogen Receptors

, 2007
A number of luminescent transition metal complexes possess rich photophysical and photochemical properties that allow them to serve as useful labels and probes for biological molecules.
Zhu, N, Sze, KS, Lee, TKM, Chung, CK, Zhang, KY, Lau, JSY, Li, CK, Ng, DCM, Hui, WK, Tsang, KHK, Lo, KKW   +10 more
core   +1 more source

A Cell Line for Detection of Botulinum Neurotoxin Type B

Frontiers in Pharmacology, 2017
Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles.
Aleksander Rust, Ciara Doran, Rosalyn Hart, Thomas Binz, Paul Stickings, Dorothea Sesardic, Andrew A. Peden, Bazbek Davletov   +7 more
doaj   +1 more source

Enhancement of intrinsic protein luminescence in nanosized complex

Doklady Biochemistry and Biophysics, 2012
[No abstract available]
Chudinova G.K., Nagovitsyn I.A., Nikitin A.K., Kurilkin V.V., Konov V.I.   +4 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bioconjugates of Luminescent CdSe-ZnS Quantum Dots with Engineered Recombinant Proteins: Novel Self-Assembled Tools for Biosensing

, 2000
Colloidal semiconductor quantum dots (QDs) are luminescent nanoparticles with size- dependent emission spectra spanning a wide range of wavelengths in the visible and near IR.
Hedi Mattoussi, George P. Anderson, Ellen R. Goldman, Phan T. Tran, J. Matthew Mauro   +4 more
core   +1 more source

Validation of flavivirus infectious clones carrying fluorescent markers for antiviral drug screening and replication studies

Frontiers in Microbiology, 2023
Flaviviruses have emerged as major arthropod-transmitted pathogens and represent an increasing public health problem worldwide. High-throughput screening can be facilitated using viruses that easily express detectable marker proteins.
Liubov Cherkashchenko, Liubov Cherkashchenko, Nathalie Gros, Alice Trausch, Aymeric Neyret, Mathilde Hénaut, Gregor Dubois, Matthieu Villeneuve, Christine Chable-Bessia, Sébastien Lyonnais, Andres Merits, Delphine Muriaux, Delphine Muriaux   +12 more
doaj   +1 more source