Results 51 to 60 of about 1,661,313 (246)

Natural ventilation for the prevention of airborne contagion. [PDF]

, 2007
BACKGROUND: Institutional transmission of airborne infections such as tuberculosis (TB) is an important public health problem, especially in resource-limited settings where protective measures such as negative-pressure isolation rooms are difficult to ...
Navincopa, Marcos, Evans, Carlton A, Gilman, RH, Richard Rodríguez, Friedland, Jon S, Navincopa, M, Pan, W, Carlton A Evans, Jesus Chacaltana, Martínez, Carlos, Evans, CA, Ticona, Eduardo, Moore, David AJ, Oeser, Clarissa C, Carlos Martínez, Rodriguez, R, Moore, DAJ, Robert H Gilman, Pan, William, Ticona, E, Chacaltana, J, Chacaltana, Jesus, Jon S Friedland, Oeser, CC, David A J Moore, A Roderick Escombe, Gilman, Robert H, Clarissa C Oeser, Friedland, JS, Martinez, C, Marcos Navincopa, Eduardo Ticona, Escombe, AR, William Pan, Rodríguez, Richard, Escombe, A Roderick   +35 more
core   +2 more sources

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Rationale and study design of PROVHILO - a worldwide multicenter randomized controlled trial on protective ventilation during general anesthesia for open abdominal surgery

Trials, 2011
Background Post-operative pulmonary complications add to the morbidity and mortality of surgical patients, in particular after general anesthesia >2 hours for abdominal surgery.
Hedenstierna Göran, Binnekade Jan M, Hollmann Markus W, Tschernko Edda M, Hiesmayr Michael, Wrigge Hermann, Canet Jaume, Jaber Samir, Severgnini Paolo, Hemmes Sabrine NT, Putensen Christian, de Abreu Marcelo, Pelosi Paolo, Schultz Marcus J   +13 more
doaj   +1 more source

Lung-Protective Ventilation Over 6 Years at a Large Academic Medical Center: An Evaluation of Trends, Adherence, and Perceptions of Benefit

Critical Care Explorations, 2021
Objectives:. The main objective of this study was to evaluate trends in set tidal volumes across all adult ICUs at a large academic medical center over 6 years, with a focus on adherence to lung-protective ventilation (≤ 8-cc/kg ideal body weight).
Catherine A. Gao, MD, Frederick M. Howard, MD, Jonathan M. Siner, MD, Thomas D. Candido, BA, Lauren E. Ferrante, MD, MHS   +4 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Interpretation and use of intraoperative protective ventilation parameters: a scoping review

, 2022
Thirty years ago, the traditional approach to mechanical ventilation consisted of the normalization of PaCO2 and pH at the expense of using a tidal volume (VT) of 10–15 mL kg-1.
Alejandro Placenti, Franco Fratebianchi
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Protective Mechanical Ventilation Modes İn The ICU: Contemporary Approaches, Clinical Applications and Their Association With Infections

Current Research in Health Sciences
In patients with respiratory failure, mechanical ventilation is the most basic treatment for intensive care patients. This treatment management is indispensable to ensure normal oxygen and carbon dioxide levels.
Özgür Özmen, Muhammet Ahmet Karakaya
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Combined lung and brain ultrasonography for an individualized “brain-protective ventilation strategy” in neurocritical care patients with challenging ventilation needs

Critical Ultrasound Journal, 2018
When intracranial hypertension and severe lung damage coexist in the same clinical scenario, their management poses a difficult challenge, especially as concerns mechanical ventilation management.
Francesco Corradi, Chiara Robba, Guido Tavazzi, Gabriele Via   +3 more
doaj   +1 more source