Results 61 to 70 of about 1,661,313 (246)

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Clinical practice of one-lung ventilation in mainland China: a nationwide questionnaire survey

BMC Anesthesiology
Background Limited information is available regarding the application of lung-protective ventilation strategies during one-lung ventilation (OLV) across mainland China.
Hong-jin Liu, Yong Lin, Wang Li, Hai Yang, Wen-yue Kang, Pei-lei Guo, Xiao-hui Guo, Ning-ning Cheng, Jie-chao Tan, Yi-na He, Si-si Chen, Yan Mu, Xian-wen Liu, Hui Zhang, Mei-fang Chen   +14 more
doaj   +1 more source

Application of intraoperative lung-protective ventilation varies in accordance with the knowledge of anaesthesiologists: a single-Centre questionnaire study and a retrospective observational study

BMC Anesthesiology, 2018
Background The benefits of lung-protective ventilation (LPV) with a low tidal volume (6 mL/kg of ideal body weight [IBW]), limited plateau pressure (
Seung Hyun Kim, Sungwon Na, Woo Kyung Lee, Hyunwoo Choi, Jeongmin Kim   +4 more
doaj   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Patients with uninjured lungs may also benefit from lung-protective ventilator settings [version 1; referees: 2 approved]

F1000Research, 2017
Although mechanical ventilation is a life-saving strategy in critically ill patients and an indispensable tool in patients under general anesthesia for surgery, it also acts as a double-edged sword.
Roger Alencar, Vittorio D'Angelo, Rachel Carmona, Marcus J Schultz, Ary Serpa Neto   +4 more
doaj   +1 more source

Circuit Compliance Compensation in Lung Protective Ventilation

, 2006
Lung protective ventilation utilizes low tidal volumes to ventilate patients with severe lung pathologies. The compensation of breathing circuit effects, i.e.
S. A. SCIUTO, G. M. P. MASSELLI, P. CAPPA, SCIUTO, SALVATORE ANDREA, S. SILVESTRI, CAPPA, Paolo   +5 more
core   +1 more source

The effects on arterial haemoglobin oxygen saturation and on shunt of increasing cardiac output with dopamine or dobutamine during one-lung ventilation [PDF]

, 2004
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsTheoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial saturation should improve as the ...
Russell, W., James, M.
core   +1 more source

Microfluidic Gratings for X‐Ray Phase Contrast Imaging

Advanced Science, EarlyView.
This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...
Alessandro Rossi, Antonio Ferraro, Francesco Coccimiglio, Tiziana Ritacco, Alberto Astolfo, Michele Giocondo, Vincenzo Formoso, Raffaele Giuseppe Agostino, Francesco Iacoviello, Ioannis Papakonstantinou, Alessandro Olivo   +10 more
wiley   +1 more source

A review of intraoperative protective ventilation

Anesthesiology and Perioperative Science
Mechanical ventilation is an important life-saving therapy for general anesthesia and critically ill patients, but ventilation itself may be accompanied with lung injury.
Yuanyuan Zou, Zhiyun Liu, Qing Miao, Jingxiang Wu   +3 more
doaj   +1 more source

Clinical implication of monitoring regional ventilation using electrical impedance tomography

Journal of Intensive Care, 2019
Mechanical ventilation can initiate ventilator-associated lung injury (VALI) and contribute to the development of multiple organ dysfunction. Although a lung protective strategy limiting both tidal volume and plateau pressure reduces VALI, uneven ...
Atsuko Shono, Toru Kotani
doaj   +1 more source