Results 71 to 80 of about 1,661,313 (246)

SOLVe: a closed-loop system focused on protective mechanical ventilation

BioMedical Engineering OnLine, 2023
Background Mechanical ventilation is an essential component in the treatment of patients with acute respiratory distress syndrome. Prompt adaptation of the settings of a ventilator to the variable needs of patients is essential to ensure personalised and
Philip von Platen, Philipp A. Pickerodt, Martin Russ, Mahdi Taher, Lea Hinken, Wolfgang Braun, Rainer Köbrich, Anake Pomprapa, Roland C. E. Francis, Steffen Leonhardt, Marian Walter   +10 more
doaj   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Extracorporeal support to achieve lung-protective and diaphragm-protective ventilation

, 2020
Purpose of reviewExtracorporeal support allows ultraprotective controlled and assisted ventilation, which can prevent lung and diaphragm injury. We focused on most recent findings in the application of extracorporeal support to achieve lung protection ...
Carlesso E., Mauri T., Spinelli E.
core   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Esophageal pressure guided closed-loop ventilation: A theoretical framework toward precision mechanical ventilation

Journal of Mechanical Ventilation
Background Esophageal balloon manometry is a surrogate for pleural pressure and has been in clinical use for decades. The main advantages for its use are to partition the total lung and chest wall mechanics, thus providing transpulmonary inspiratory ...
Ehab G Daoud
doaj   +1 more source

Perioperative lung protective ventilation in obese patients

, 2015
The perioperative use and relevance of protective ventilation in surgical patients is being increasingly recognized. Obesity poses particular challenges to adequate mechanical ventilation in addition to surgical constraints, primarily by restricted lung ...
Repine, John E., Serpa Neto, Ary, Fernandez-Bustamante, Ana, Vidal Melo, Marcos F., Moine, Pierre, Hashimoto, Soshi   +5 more
core   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Establishing an in vivo large animal model of one-lung ventilation and operative lung trauma.

PLoS ONE
BackgroundRespiratory complications, including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), are important causes of morbidity and mortality among lung surgery patients. Lung surgery introduces surgical and atelectatic trauma to
Catherine Giffin, Jay Kormish, Martha Hinton, Shyamala Dakshinamurti, Ruth Graham, Biniam Kidane   +5 more
doaj   +1 more source

PROtective Ventilation with a low versus high Inspiratory Oxygen fraction (PROVIO) and its effects on postoperative pulmonary complications: protocol for a randomized controlled trial

Trials, 2019
Background Postoperative pulmonary complications (PPCs) are the most common perioperative complications following surgical site infection (SSI). They prolong the hospital stay and increase health care costs.
Xue-Fei Li, Dan Jiang, Yu-Lian Jiang, Hong Yu, Jia-Li Jiang, Lei-Lei He, Xiao-Yun Yang, Hai Yu   +7 more
doaj   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source