Results 71 to 80 of about 1,003,686 (240)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

PALLIATION AND LIFE QUALITY IN LUNG-CANCER - HOW GOOD ARE CLINICIAN AT JUDGING TREATMENT OUTCOME [PDF]

, 1991
A recent trial by the MRC Lung Cancer Working Party used physician assessments to compare two palliative schedules of radiotherapy in lung cancer.
Cooke, NT, Jones, PW, Regan, J, Yarnold, J   +3 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Expression and Clinical Significance of PD-1 and PD-L1 in Pulmonary Carcinoids

Chinese Journal of Lung Cancer, 2016
Background and objective The incidence of pulmonary carcinoid (PC) is very rare in primary lung malignant tumors, and the prognosis of this disease is closely associated with its pathological features. In this study, the expressions of programmed death 1
Mingbiao LI, Song XU, Haiyang FAN, Hongyi ZHANG, Ying LI, Yongwen LI, Minghui LIU, Hongyu LIU, Jun CHEN   +8 more
doaj   +1 more source

MicroRNAs in lung cancer [PDF]

, 2017
Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this ...
An, Baltimore, Belinsky, Brennan, Chen, De Flora, De Flora, Dong, Duan, Gomez, Hao, Harris, Hasegawa, Haugen, Hu, Inoue, Jemal, Jia, Lam, Li, Liu, Nakanishi, Neilson, O'Driscoll, Pan, Peiper, Ren, Schmeck, Schrump, Sensinger, Shah, Slack, Speiser, Stampfli, Wang, Wang, Yoshida, You, Zhang, Zhang, Zienolddiny   +40 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer [PDF]

, 2018
Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine
Bruno, P, D'Ascanio, M, Fiorentino, C, Grieco, A, Mancini, R, Pezzuto, A, Ricci, A, Sposato, B   +7 more
core   +1 more source

Lung Cancer Screening [PDF]

Chest, 2002
Matthew Stanbrook and Ken Flegel caution patience in waiting for better evidence before implementing lung cancer screening programs with computerized tomography for Canadians, despite mean survival times for screen-detected lung cancer of more than 5 years in the context of the International ...
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs) [PDF]

, 2018
BACKGROUND: Although patients with advanced or metastatic lung cancer have poor prognosis, admission to the ICU for management of life-threatening complications has increased over the years.
A Steven, A-C Barbot, A-C Toffart, AK Adam, C Hamard, CA Reichner, CG Slatore, DV Schapira, E Azoulay, E Azoulay, E Biskup, F Vincent, FS Taccone, JI Salluh, JL Vincent, JR Gall Le, K Puxty, M Früh, M Garrouste-Orgeas, M Maltoni, M Soares, M Soares, M Soares, ME Charlson, MM Oken, MR Bonomi, P Zarogoulidis, R Fisher, RR Jennens, S Anisoglou, S Roques, T Cooksley, T Tanvetyanon, X Nan, Y Zerbib, Y-F Chen, YJ Kim   +36 more
core   +2 more sources