Results 61 to 70 of about 4,636,683 (298)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Unlocking biomarker discovery: Large scale application of aptamer proteomic technology for early detection of lung cancer [PDF]

, 2010
Lung cancer is the leading cause of cancer deaths, because ~84% of cases are diagnosed at an advanced stage. Worldwide in 2008, ~1.5 million people were diagnosed and ~1.3 million died – a survival rate unchanged since 1960.
Alex Stewart, Stewart, A, Joel L Weissfeld, William L. Bigbee, Mehan Mike, Rom, William N, Stewart, Alex, Gold Larry, Miller, YE, Edward N. Brody, William N Rom, Weissfeld, JL, Harvey I Pass, Siegfried, JM, Pass Harvey I., Stephen Williams, Siegfried, Jill M, Walker, Jeffrey J, Walker Jeffrey J., Bigbee, William L, William L Bigbee, Pass, Harvey I, Rachel M Ostroff, Ostroff, RM, Weissfeld Joel L., Gold, Larry, Bigbee William L., York E. Miller, Zichi Dom, York E Miller, Weissfeld, Joel L, William N. Rom, Gold, L, Franklin Wilbur, Joel L. Weissfeld, Edward N Brody, Franklin, Wilbur, Williams Stephen, Rom, WN, Miller York E., Jeffrey J Walker, Franklin, W, Zichi, D, Mehan, M, Miller, York E, Harvey I. Pass, Brody, EN, Bigbee, WL, Ostroff, Rachel M, Walker, JJ, Rom William N., Williams, Stephen, Dom Zichi, Stewart Alex, Pass, HI, Mehan, Mike, Wilbur Franklin, Brody Edward N., Siegfried Jill M., Mike Mehan, Williams, S, Zichi, Dom, Jill M Siegfried, Rachel M. Ostroff, Ostroff Rachel M., Jeffrey J. Walker, Jill M. Siegfried, Larry Gold, Brody, Edward N   +68 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian [PDF]

, 2009
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung cancer in Mongolia of China.
Guang Wang, Zhi-Xie Zhang, Qin Yin, Jia Ma, Fuhou Chang, Min-jie Wang, Jun QI   +6 more
core  

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma [PDF]

, 2011
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis.
Joana Carrola, Brian J. Goodfellow, Carreira, Isabel M., Goodfellow, Brian J., Rocha, Cláudia M., Gil, Ana M., Carvalho, Lina, Cláudia M. Rocha, António S. Barros, Lina Carvalho, Barros, António S., Ana Gomes, Bernardo, Joao, Carrola, Joana, Sousa, Vitor, Ana M. Gil, João Bernardo, Vitor Sousa, Gomes, Ana, Iola F. Duarte, Isabel M. Carreira, Duarte, Iola F.   +21 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.

, 2007
Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility.
Pharoah, Paul DP, Hogervorst, Frans BL, Dunning, Alison M, Nevanlinna, Heli A, Blomqvist, Carl,, Tommiska, Johanna, Healey, Catherine S, Pharoah, Paul D P, Tollenaar, Rob A E M, Reincke, Scarlett, Peto, Julian, Blomqvist, Carl, Van't Veer, Laura J, Johnson, Nichola, Fletcher, Olivia, Tollenaar, Rob AEM, Broeks, Annegien, Schmidt, Marjanka K, Braaf, Linde M, Hogervorst, Frans B L, Breast Cancer Association Consortium, Easton, Douglas F, Dörk, Thilo   +22 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source