Results 11 to 20 of about 269,803 (346)

Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics. [PDF]

Pharm Res, 2023
Drescher SK, Jiao Y, Chen MJ, Kurumaddali A, Shao J, Amini E, Hochhaus G, Bulitta JB.   +7 more
europepmc   +3 more sources

A new method for measuring lung deposition efficiency of airborne nanoparticles in a single breath. [PDF]

Sci Rep, 2016
Jakobsson JK, Hedlund J, Kumlin J, Wollmer P, Löndahl J.   +4 more
europepmc   +3 more sources

Variations in coil temperature/power and e-liquid constituents change size and lung deposition of particles emitted by an electronic cigarette. [PDF]

Physiol Rep, 2019
Lechasseur A, Altmejd S, Turgeon N, Buonanno G, Morawska L, Brunet D, Duchaine C, Morissette MC.   +7 more
europepmc   +3 more sources

Zinc Oxide Nanoparticles Promote YAP/TAZ Nuclear Localization in Alveolar Epithelial Type II Cells

Atmosphere, 2022
We investigated roles of Hippo signaling pathway components in alveolar type II cells (AECII) after zinc oxide nanoparticle (ZnONP) exposure. ZnONPs physicochemistry was characterized using field emission-scanning electron microscopy (FE-SEM) and energy ...
Vincent Laiman, Didik Setyo Heriyanto, Yueh-Lun Lee, Ching-Huang Lai, Chih-Hong Pan, Wei-Liang Chen, Chung-Ching Wang, Kai-Jen Chuang, Jer-Hwa Chang, Hsiao-Chi Chuang   +9 more
doaj   +1 more source

Deposition of Inhaled Levofloxacin in Cystic Fibrosis Lungs Assessed by Functional Respiratory Imaging

Pharmaceutics, 2021
Pulmonary infections caused by Pseudomonas aeruginosa (PA) represent the leading cause of pulmonary morbidity in adults with cystic fibrosis (CF). In addition to tobramycin, colistin, and aztreonam, levofloxacin has been approved in Europe to treat PA ...
Carsten Schwarz, Claudio Procaccianti, Benjamin Mignot, Hosein Sadafi, Nicolas Schwenck, Xabier Murgia, Federico Bianco   +6 more
doaj   +1 more source

Modeled Respiratory Tract Deposition of Aerosolized Oil Diluents Used in Δ9-THC-Based Electronic Cigarette Liquid Products

Frontiers in Public Health, 2021
Electronic cigarette, or vaping, products (EVP) heat liquids (“e-liquids”) that contain substances (licit or illicit) and deliver aerosolized particles into the lungs.
Anand Ranpara, Aleksandr B. Stefaniak, Kenneth Williams, Elizabeth Fernandez, Ryan F. LeBouf   +4 more
doaj   +1 more source

Novel Insights into Aspergillus fumigatus Pathogenesis and Host Response from State-of-the-Art Imaging of Host–Pathogen Interactions during Infection

Journal of Fungi, 2022
Aspergillus fumigatus spores initiate more than 3,000,000 chronic and 300,000 invasive diseases annually, worldwide. Depending on the immune status of the host, inhalation of these spores can lead to a broad spectrum of disease, including invasive ...
Sébastien C. Ortiz, Katie Pennington, Darren D. Thomson, Margherita Bertuzzi   +3 more
doaj   +1 more source

Co-Delivery of a High Dose of Amphotericin B and Itraconazole by Means of a Dry Powder Inhaler Formulation for the Treatment of Severe Fungal Pulmonary Infections

Pharmaceutics, 2023
Over the past few decades, there has been a considerable rise in the incidence and prevalence of pulmonary fungal infections, creating a global health problem due to a lack of antifungal therapies specifically designed for pulmonary administration ...
Salomé S. Celi, Raquel Fernández-García, Andreina I. Afonso-Urich, M. Paloma Ballesteros, Anne Marie Healy, Dolores R. Serrano   +5 more
doaj   +1 more source

Asymmetric lung increases particle filtration by deposition

Scientific Reports, 2023
AbstractHuman lung is known to be an asymmetric dichotomously branched network of bronchioles. Existing literature on the relation between anatomy and air-flow physics in the tracheobronchial trees has discussed the results of asymmetry. We discuss a secondary (but an important) lung function to seek asymmetry: to protect the acinus from a high ...
Debjit Kundu, Mahesh V. Panchagnula
openaire   +3 more sources

Radiolabeling Method for Lyophilizate for Dry Powder Inhalation Formulations

Pharmaceutics, 2022
Human lung deposition data is non-mandatory for drug approval but very useful for the development of orally inhaled drug products. Lung deposition of inhaled drugs can be quantified by radionuclide imaging, for which one of the first considerations is ...
Kahori Miyamoto, Tomomi Akita, Chikamasa Yamashita   +2 more
doaj   +1 more source