Results 61 to 70 of about 269,803 (346)

An In Vitro–In Vivo Comparison of Two Levodopa Dry Powder Products for Inhalation: A Randomized Trial Comparing Inbrija and Levodopa Cyclops

Pharmaceutics
Background/Objectives: The pulmonary administration of levodopa enables a rapid absorption and onset of action, making it a suitable administration route for managing OFF episodes in Parkinson’s disease.
Julia M. E. Berends, Ettina J. Wimmenhove, Marcel Hoppentocht, Paul Hagedoorn, Henderik W. Frijlink, Floris Grasmeijer   +5 more
doaj   +1 more source

Aerosol Delivery of Surfactant Liposomes for Management of Pulmonary Fibrosis: An Approach Supporting Pulmonary Mechanics

Pharmaceutics, 2021
Excessive architectural re-modeling of tissues in pulmonary fibrosis due to proliferation of myofibroblasts and deposition of extracellular matrix adversely affects the elasticity of the alveoli and lung function.
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Lenah S. Binmahfouz, Rana Bakur Bakhaidar, Nagaraja Sreeharsha, Anroop B. Nair, Chandramouli Ramnarayanan   +7 more
doaj   +1 more source

Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility [PDF]

, 2005
Inhaled prostacyclin (PGI(2)) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular ( RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility.
B. Zwissler, Burghuber OC, C. Hofstetter, E. Thein, F. Meisner, G. Kemming, H. Kisch-Wedel, Hardy C, Hoegl S, Holt JP, Kass D, Kieler JN, Kisch-Wedel H, M. Flondor, Maughan WL, Metsa KT, Pavlovic M, Roberts AM, S. Bruhn, Task, van der Velde ET, van Heerden PV, W. Kreyling, Welte M, Zwissler B   +24 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Side lying during nebulisation can significantly improve apical deposition in healthy adults and adults with mild cystic fibrosis lung disease: a randomised crossover trial

BMC Pulmonary Medicine, 2019
Background In people with and without Cystic Fibrosis (CF), does side lying during nebulisation change: the proportion of the dose loaded in the nebuliser that is deposited in the lungs; the uniformity of deposition throughout the lungs; or the apical ...
Ruth L. Dentice, Mark R. Elkins, Jordan Verschuer, Stefan Eberl, Genevieve Dwyer, Peter T. P. Bye   +5 more
doaj   +1 more source

LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation

Acta Pharmaceutica Sinica B, 2022
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unknown etiology and limited therapeutic options. Activation of fibroblasts is a prominent feature of pulmonary fibrosis.
Jian Sun, Tongzhu Jin, Zhihui Niu, Jiayu Guo, Yingying Guo, Ruoxuan Yang, Qianqian Wang, Huiying Gao, Yuhan Zhang, Tianyu Li, Wenxin He, Zhixin Li, Wenchao Ma, Wei Su, Liangliang Li, Xingxing Fan, Hongli Shan, Haihai Liang   +17 more
doaj   +1 more source

Tissue eosinophilia and eosinophil degranulation in Riedel's invasive fibrous thyroiditis. [PDF]

, 1996
The etiology of Riedel's invasive fibrous thyroiditis (IFT) has remained obscure. This rare disorder has been confused in the past with the more common fibrous variant of Hashimoto's disease.
Bahn, R. S., Gleich, G. J., Goellner, J. R., Hay, I. D., Heufelder, Armin E.   +4 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A Monte Carlo-Based 3D Whole Lung Model for Aerosol Deposition Studies: Implementation and Validation

Bioengineering
A detailed picture of how an aerosol is transported and deposited in the self-affine bronchial tree structure of patients is fundamental to design and optimize orally inhaled drug products.
Georgi Hristov Spasov, Ciro Cottini, Andrea Benassi   +2 more
doaj   +1 more source

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae [PDF]

, 2014
Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved
AA Humbles, AD Doyle, AD Klion, AE O'Connell, AM Galioto, Anita Y. N. Cheung, Ashleigh C. Johnston, BA Vallance, CA Gray, CA Gray, CS Enobe, D Abraham, D Voehringer, DR Herbert, E Pearlman, E Pinelli, EA Jacobsen, Emma T. Cadman, ET Cadman, H Kita, James J. Lee, JE Simons, JE Simons, JH Schroeder, JJ Lee, Katherine A. Thysse, KJ Hamann, KL Denzler, KL Denzler, L Le Goff, L O'Bryan, LA Spencer, LR Hall, M Lomask, M Witzenrath, ML Knott, PC Fulkerson, PL Milton, RA Lawrence, RA Lawrence, Rachel A. Lawrence, RK Mehlotra, S Pegorier, S Specht, SA Babayan, SI Ochkur, Siobhan Bearder, T Carter, T Ramalingam, T Ramalingam, Thomas B. Nutman, V Fabre, W Mitzner   +52 more
core   +4 more sources