CXCR4+granulocytes reflect fungal cystic fibrosis lung disease [PDF]
European Respiratory Journal, 2015 Cystic fibrosis airways are frequently colonised with fungi. However, the interaction of these fungi with immune cells and the clinical relevance in cystic fibrosis lung disease are incompletely understood.We characterised granulocytes in airway fluids and peripheral blood from cystic fibrosis patients with and without fungal colonisation, non-cystic ...
Anurag Singh +6 more
openaire +3 more sources
The lung microbiome: progress and promise.
Journal of Clinical Investigation, 2021 The healthy lung was long thought of as sterile, but recent advances using molecular sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely reflect communities present in the upper respiratory tract that enter the lung ...
S. Whiteside, J. McGinniss, R. Collman
semanticscholar +1 more source
Invasive pulmonary aspergillosis complicating COVID-19 in the ICU - A case report. [PDF]
, 2021 It is not yet known, if critically ill COVID-19 patients are prone to fungal infections. We report a 69-year-old patient without typical risk factors for invasive pulmonary aspergillosis (IPA), who developed IPA two weeks after onset of symptoms.
Eller, Philipp +5 more
core
A survey of fungal microbiota in airways of healthy volunteer subjects from Puglia (Apulia), Italy
BMC Infectious Diseases, 2019 Background The human respiratory tract represents the major portal of entry for numerous microorganisms, primarily those occurring as airborne particles such as viral and bacterial entities, or fungal spores.
Giovanna Elisiana Carpagnano +9 more
doaj +1 more source
Using Staged Tree Models for Health Data: Investigating Invasive Fungal Infections by Aspergillus and Other Filamentous Fungi [PDF]
arXiv, 2023 Machine learning models are increasingly used in the medical domain to study the association between risk factors and diseases to support practitioners in predicting health outcomes. In this paper, we showcase the use of machine-learned staged tree models for investigating complex asymmetric dependence structures in health data.
arxiv
Allogeneic Hematopoietic Stem Cell Transplantation Despite Severe <i>Fusarium solani</i> Infection in a Lung Transplanted Patient-A Case Report. [PDF]
MicroorganismsSolid-organ transplant patients require prolonged immunosuppression, increasing their risk of hematologic disorders. For these conditions, allogeneic hematopoietic stem cell transplantation (HSCT) is a potential treatment, but it carries significant risk
Tozzi M +18 more
europepmc +2 more sources
Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. [PDF]
, 2020 There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of ...
Alkhazraji, Sondus +8 more
core +1 more source
Multicentric Case Series and Literature Review of Coccidioidal Otomastoiditis
Emerging Infectious Diseases, 2023 Coccidioidomycosis involving the ear, mastoid bone, or both is uncommon. We describe 5 new cases from the United States and review 4 cases reported in the literature of otomycosis and mastoiditis caused by Coccidioides.
Ilan S. Schwartz +7 more
doaj +1 more source
Open Forum Infectious DiseasesAmong solid organ transplant recipients taking belatacept, 15% developed invasive fungal diseases. The most common invasive fungal diseases were aspergillosis (56%) and candidiasis (22%).
E. Bell +3 more
semanticscholar +1 more source
Infection and Immunity, 2018 Tumor necrosis factor (TNF) antagonists are popular therapies for inflammatory diseases. These agents enhance the numbers and function of regulatory T cells (Tregs), which are important in controlling inflammatory diseases.
Jamie L. Tweedle, G. Deepe
semanticscholar +1 more source