Results 51 to 60 of about 3,149,992 (309)

CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. [PDF]

, 2010
When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communication
Topal Hüsnü, Maccallum, Donna M., Hall, Rebecca, Fritz A. Mühlschlegel, Gow, Neil A R, Hall, Rebecca A., Rebecca A Hall, Bloor, JW, Bloor James W., Neil A. R. Gow, Steegborn Clemens, James W, Bloor, James W., Muehlschlegel, Fritz A, Rebecca A. Hall, Buck, Jochen, Hall, RA, Wang Yue, Gow, Neil A. R., Hüsnü Topal, Hall Rebecca A., Buck Jochen, Fritz A Mühlschlegel, Eaton Rebecca, Wang, Yue, Donna M. Maccallum, Mühlschlegel Fritz A., MacCallum, Donna M, De Sordi, Luisa, Levin Lonny R., Gary K Robinson, Jochen Buck, Maccallum, DM, James W. Bloor, Steegborn, Clemens, Neil A R Gow, Topal, Husnu, Mühlschlegel, Fritz A, MacCallum Donna M., Eaton, R, De Sordi, L, Levin, LR, Gary K. Robinson, Steegborn, C, Rebecca Eaton, Luisa De Sordi, Mühlschlegel, FA, Clemens Steegborn, Robinson, GK, Lonny R Levin, Mühlschlegel, Fritz A., De Sordi Luisa, Wang, Y, Levin, Lonny R., Gow Neil A. R., Donna M Maccallum, Levin, Lonny R, Topal, Huesnue, Topal, H, Robinson, Gary K, Gow, NA, Lonny R. Levin, Eaton, Rebecca, James W Bloor, Hall, Rebecca; id_orcid, Bloor, James W, Robinson Gary K., Buck, J, Yue Wang, Robinson, Gary K.   +69 more
core   +1 more source

The bacterial and fungal communities in the airways of adults with asthma and eosinophilic lung diseases [PDF]

, 2020
Asthma is the most common long-term respiratory condition, but its aetiology is not fully understood. The incidence has increased alongside urbanisation and altered microbial exposure patterns. The respiratory tract’s bacterial communities (microbiota)
McBrien, Claire Nichola
core   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Mycotic Infections Acquired outside Areas of Known Endemicity, United States

Emerging Infectious Diseases, 2015
In the United States, endemic mycoses—blastomycosis, coccidioidomycosis, and histoplasmosis—pose considerable clinical and public health challenges. Although the causative fungi typically exist within broadly defined geographic areas or ecologic niches ...
Kaitlin Benedict, George R. Thompson, Stan Deresinski, Tom M. Chiller   +3 more
doaj   +1 more source

Not all Nodules Are Cancer and not all Fungal Infections Are Aspergillus

Acta Médica Portuguesa, 2022
Pithomyces, a dematiaceous fungus, is a common colonizer of dead leaves and stems of many different plants and is associated with facial eczema in some animals.
Ana Fonseca, David Afonso-João, Gabriela Abreu, Daniel Coutinho   +3 more
doaj   +1 more source

Fungal Infections in Pediatric Lung Transplant Recipients: Colonization and Invasive Disease [PDF]

The Journal of Heart and Lung Transplantation, 2009
The purpose of this study was to evaluate the epidemiology and investigate the impact of colonization and pulmonary fungal infections (PFIs).In this investigation we performed a retrospective analysis of 55 pediatric lung transplant recipients from 2002 to 2007 at a single institution.
Michael, Liu, Sarah, Worley, George B, Mallory, Sarah, Arrigain, John, Robertson, Marc G, Schecter, Okan, Elidemir, Lara A, Danziger-Isakov   +7 more
openaire   +2 more sources

Chronic obstructive pulmonary disease: a complex comorbidity of lung cancer [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a major burden throughout the world. It is associated with a significantly increased incidence of lung cancer and may influence treatment options and outcome.
Derek Grose MRCP, FRCR, Robert Milroy, Grose, Derek, Milroy, Robert   +3 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source