Results 61 to 70 of about 1,528,999 (362)

Atypical Pulmonary Tuberculosis as the First Manifestation of Advanced HIV Disease—Diagnostic Difficulties

Diagnostics, 2022
Tuberculosis (TB) is the leading cause of morbidity, hospitalisations, and mortality in people living with HIV (PLWH). The lower CD4+ T-lymphocyte count in the course of HIV infection, the higher risk of active TB, and the higher odds for atypical ...
Aneta Kacprzak, Karina Oniszh, Regina Podlasin, Maria Marczak, Iwona Cielniak, Ewa Augustynowicz-Kopeć, Witold Tomkowski, Monika Szturmowicz   +7 more
doaj   +1 more source

Recent advances in interstitial lung disease research [PDF]

, 2006
The interstitial lung diseases are a diverse collection of disorders characterized by impaired gas exchange, restricted physiology on lung function testing, and diffuse parenchymal lung infiltrates on radiography.
Vassallo, Robert
core  

Human epididymis protein 4 (HE4) in benign and malignant diseases [PDF]

, 2012
Background: Human epididymis protein 4 (HE4) is described as a useful new biomarker in ovarian cancer. As HE4 is neither tumor nor organ specific, we intensively investigated the occurrence of this protein in female and male patients with various benign ...
Anastasi, Anastasi, Andersen, Andersen, Bast, Bast, Drapkin, Drapkin, Duffy, Duffy, Escudero, Escudero, Galgano, Galgano, Heintz, Heintz, Hellstrom, Hellstrom, Hellstrom, Hellstrom, Holcomb, Holcomb, Huhtinen, Huhtinen, Jacob, Jacob, Jacobs, Jacobs, Kurman, Kurman, Liu, Liu, Montagnana, Montagnana, Moore, Moore, Nolen, Nolen, Tuxen, Tuxen   +39 more
core   +1 more source

Lung Ultrasonography in the Evaluation of Late Sequelae of COVID-19 Pneumonia—A Comparison with Chest Computed Tomography: A Prospective Study

Viruses
The onset of the COVID-19 pandemic allowed physicians to gain experience in lung ultrasound (LUS) during the acute phase of the disease. However, limited data are available on LUS findings during the recovery phase.
Katarzyna Zimna, Małgorzata Sobiecka, Jacek Wakuliński, Dorota Wyrostkiewicz, Ewa Jankowska, Monika Szturmowicz, Witold Z. Tomkowski   +6 more
doaj   +1 more source

Both T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SSc

Arthritis Research & Therapy, 2022
Background Recently, a novel humanized mouse model for systemic sclerosis (SSc) was established by transferring peripheral blood mononuclear cells (PBMC) from patients with SSc to Rag2 −/− Il2rg −/− immunodeficient mice. Here, we aimed to investigate the
Yaqing Shu, Xiaoyang Yue, Jacqueline Wax, Brigitte Kasper, Junping Yin, Xiaoqing Wang, Liang Zhang, Marjan Ahmadi, Harald Heidecke, Antje Müller, Peter Lamprecht, Xinhua Yu, Gabriela Riemekasten, Frank Petersen   +13 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Regression of murine lung tumors by the let-7 microRNA. [PDF]

, 2010
MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer.
Bader, AG, Brown, D, Homer, R, Kelnar, K, Medina, PP, Omotola, M, Ruffino, L, Slack, FJ, Trang, P, Weidhaas, JB, Wiggins, JF   +10 more
core   +2 more sources

Neutrophil-to-Lymphocyte and Platelet Ratio (N/LP Ratio), a Reliable Criterion for Predicting In-Hospital Mortality in Both Genders Infected With SARS-CoV-2

Mediators of Inflammation
Conclusion: A reliable predictor in the current study of men and women with COVID-19 was N/LP ratio.
Jafar Mohammadshahi, Hassan Ghobadi, Afshan Shargi, Hossein Moradkhani, Hamed Rezaei, Mahur Kazemy, Mohammad Reza Aslani   +6 more
doaj   +1 more source

Does optimized adherence support improve treatment outcomes in RR / MDR-TB patients on 18-20 months regimen in Tbilisi, Georgia?

Journal of Infection in Developing Countries, 2021
Introduction: Adherence to second-line antituberculosis drug is challenging. A combination of strategies needs to be implemented to achieve adherence.
Tinatin Jomidava, Mohammed Khogali, Yuliia Sereda, Zaza Avaliani, Malkhaz Davitashvili, Mikheil Madzgharashvili, Nestan Tukvadze, Lali Chaphurishvili, Mamuka Chincharauli, Maia Kipiani   +9 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source