Results 71 to 80 of about 3,911,704 (314)

Does optimized adherence support improve treatment outcomes in RR / MDR-TB patients on 18-20 months regimen in Tbilisi, Georgia?

Journal of Infection in Developing Countries, 2021
Introduction: Adherence to second-line antituberculosis drug is challenging. A combination of strategies needs to be implemented to achieve adherence.
Tinatin Jomidava, Mohammed Khogali, Yuliia Sereda, Zaza Avaliani, Malkhaz Davitashvili, Mikheil Madzgharashvili, Nestan Tukvadze, Lali Chaphurishvili, Mamuka Chincharauli, Maia Kipiani   +9 more
doaj   +1 more source

The lung microbiome in interstitial lung disease

Breathe
Interstitial lung disease (ILD) is a heterogeneous chronic form of lung disease. The pathogenesis of ILD is poorly understood and a common form of ILD, idiopathic pulmonary fibrosis (IPF) is associated with poor prognosis. There is evidence for substantial dysregulated immune responses in ILD.
Mikhail, Sheridan G., O'Dwyer, David N.
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Integrated Bayesian approach to incorporate prior biological knowledge in the investigation of genetic variants associated with lung function [PDF]

, 2018
Genetic association studies aim to identify single-nucleotide polymorphisms (SNPs) that are associated with complex diseases and traits. These studies, especially those performed at the genome-wide level, have successfully identified many SNPs associated
Pereira, M
core   +1 more source

Medicinal Plant-Based Advanced Drug Delivery System for the Treatment of Chronic Lung Diseases

, 2023
Lung disease represents a significant medical problem worldwide. They are usually treated by different synthetic drugs. Yet, incessant high-portion of oral and injectable medications may prompt extreme side effects and at this crossroad, there is a ...
Dua, K, Sarin, A, Verma, N
core   +1 more source

The Clinical Value of Cyfra 21-1 Estimation for Lung Cancer Patients

The International Journal of Biological Markers, 1996
Cytokeratin-19, one of the cytoskeletal proteins, is expressed both in bronchial epithelium and in lung cancer cells. The aim of our study was to establish the value of serum cytokeratin-19 soluble fragment (Cyfra 21-1) measurement in lung cancer ...
M. Szturmowicz, A. Sakowicz, P. Rudzinski, J. Zych, E. Wiatr, J. Zalęska, E. Rowinska-Zakrzewska   +6 more
doaj   +1 more source

Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis

Respiratory Research, 2022
Background Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD), including a few with sarcoidosis.
M. C. Schimmelpennink, D. B. Meek, A. D. M. Vorselaars, L. C. M. Langezaal, C. H. M. van Moorsel, J. J. van der Vis, M. Veltkamp, J. C. Grutters   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Classification of lung disease in HRCT scans using integral geometry measures and functional data analysis [PDF]

, 2010
A framework for classification of chronic lung disease from high-resolution CT scans is presented. We use a set of features which measure the local morphology and topology of the 3D voxels within the lung parenchyma and apply functional data classification
Bhalerao, Abhir, Thönnes, Elke, Parr, David   +2 more
core   +1 more source

MARCKS and Lung Disease [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2019
Abstract MARCKS (myristoylated alanine-rich C kinase substrate) is a prominent PKC substrate expressed in all eukaryotic cells. It is known to bind to and cross-link actin filaments, to serve as a bridge between Ca2+/calmodulin and PKC signaling, and to sequester the signaling molecule phosphatidylinositol 4,5-bisphosphate in the ...
Mary K, Sheats, Qi, Yin, Shijing, Fang, Joungjoa, Park, Anne L, Crews, Indu, Parikh, Brian, Dickson, Kenneth B, Adler   +7 more
openaire   +2 more sources