Results 61 to 70 of about 4,088,704 (313)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Pulmonary hypertension in diffuse parenchymal lung diseases — is there any benefit of PAH-specific therapy? [PDF]

, 2017
  Pulmonary hypertension (PH) is diagnosed in 40–50% of the patients with end-stage diffuse parenchymal lung diseases (DPLD), and it is associated with significant worsening of life expectancy. Latest ERS/ESC guidelines recommend best available treatment
Kacprzak, Aneta; I Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland, Szturmowicz, Monika; I Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland, Kuś, Jan; I Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland, Monika Szturmowicz, Jan Kuś, Aneta Kacprzak   +5 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The Clinical Value of Cyfra 21-1 Estimation for Lung Cancer Patients

The International Journal of Biological Markers, 1996
Cytokeratin-19, one of the cytoskeletal proteins, is expressed both in bronchial epithelium and in lung cancer cells. The aim of our study was to establish the value of serum cytokeratin-19 soluble fragment (Cyfra 21-1) measurement in lung cancer ...
M. Szturmowicz, A. Sakowicz, P. Rudzinski, J. Zych, E. Wiatr, J. Zalęska, E. Rowinska-Zakrzewska   +6 more
doaj   +1 more source

Constrictive bronchiolitis obliterans in patient with Castelman’s disease

Monaldi Archives for Chest Disease, 2005
A 37-year-old woman with hialin- vascular type Castelman’s disease (CD) localised in the retroperitoneal region, incompletely resected, developed progressive dyspnoea. The chest radiograph taken 3 months before the operation was normal. The chest CT scan
E. Radzikowska, J. Pawlowski, M. Chabowski, R. Langfort   +3 more
doaj   +1 more source

Does optimized adherence support improve treatment outcomes in RR / MDR-TB patients on 18-20 months regimen in Tbilisi, Georgia?

Journal of Infection in Developing Countries, 2021
Introduction: Adherence to second-line antituberculosis drug is challenging. A combination of strategies needs to be implemented to achieve adherence.
Tinatin Jomidava, Mohammed Khogali, Yuliia Sereda, Zaza Avaliani, Malkhaz Davitashvili, Mikheil Madzgharashvili, Nestan Tukvadze, Lali Chaphurishvili, Mamuka Chincharauli, Maia Kipiani   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The lung microbiome in interstitial lung disease

Breathe
Interstitial lung disease (ILD) is a heterogeneous chronic form of lung disease. The pathogenesis of ILD is poorly understood and a common form of ILD, idiopathic pulmonary fibrosis (IPF) is associated with poor prognosis. There is evidence for substantial dysregulated immune responses in ILD.
Mikhail, Sheridan G., O'Dwyer, David N.
openaire   +2 more sources

MARCKS and Lung Disease [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2019
Abstract MARCKS (myristoylated alanine-rich C kinase substrate) is a prominent PKC substrate expressed in all eukaryotic cells. It is known to bind to and cross-link actin filaments, to serve as a bridge between Ca2+/calmodulin and PKC signaling, and to sequester the signaling molecule phosphatidylinositol 4,5-bisphosphate in the ...
Mary K, Sheats, Qi, Yin, Shijing, Fang, Joungjoa, Park, Anne L, Crews, Indu, Parikh, Brian, Dickson, Kenneth B, Adler   +7 more
openaire   +2 more sources

Pneumococcal infections and protection with vaccination in adult chronic lung diseases

, 2020
Pneumococcal infections are an important cause of mortality and morbidity in Chronic Lung Diseases. However, exacerbations, which make the treatment of diseases very difficult, and corticosteroids used during treatment carry a great risk of pneumococcal ...
Ozhan, Mustafa Hikmet, Pullukçu, Hüsnü, Ozlu, Tevfik, Saltoglu, Nese, Ozyurek, Berna Akinci, Kılınç, Oğuz, Olmez, Ayse, Sayıner, Abdullah, Kilinc, Oguz, Karadeniz, Gulistan, Sayiner, Abdullah, Ozhan, Mustafa, Tevfik Özlü, Berna Akıncı Özyürek, Gülistan Karadeniz, Hüsnü Pullukçu, Oğuz Kılınç, Ayşe Ölmez, Neşe Saltoğlu, Abdullah Sayıner, Mustafa Hikmet Özhan   +20 more
core   +1 more source