Results 81 to 90 of about 3,911,704 (314)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis

Respiratory Research, 2020
Background Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase, clinical phenotypes, disease ...
David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli, Paola Rottoli   +14 more
doaj   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Lung function in the general population : the complex interplay of variants in "Serpina1" and other genes with the environment [PDF]

, 2013
Background. One of the globally most frequent health problems are obstructive lung diseases such as asthma and chronic obstructive pulmonary disease.
Thun, Gian Andri
core   +1 more source

RT-PCR Misdiagnosis of Patient with Rare EGFR Mutation Lung Adenocarcinoma: Is NGS the Only Solution?

Diagnostics
Background and Clinical Significance: Molecular testing plays a crucial role in lung cancer diagnosis and management. While single-gene tests (SGTs) remain an important diagnostic tool, developments in novel methods such as next generation sequencing ...
Piotr Piekarczyk, Urszula Lechowicz, Janusz Szopiński, Mateusz Polaczek, Katarzyna Błasińska, Katarzyna Modrzewska   +5 more
doaj   +1 more source

Correction to: Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis

Respiratory Research, 2020
After publication of our article [1] the authors have notified us that one of the names has been incorrectly tagged.
David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli, Paola Rottoli   +14 more
doaj   +1 more source

Lung transplantation for interstitial lung disease

Breathe
Interstitial lung diseases (ILDs) are now the most common indication for lung transplant internationally. Given that many lung transplant candidates with idiopathic pulmonary fibrosis are older, referral to a pulmonary rehabilitation programme is important to help mitigate the adverse outcomes associated with frailty.
Ronan, Nicola J., Helly, Feargal, Murray, Michelle A.   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Lung Cancer and Interstitial Lung Diseases

Cancers
Lung cancer continues to be one of the leading causes of cancer-related death worldwide. There is evidence of a complex interplay between lung cancer and interstitial lung disease (ILD), affecting disease progression, management strategies, and patient outcomes. Both conditions develop as the result of common risk factors such as smoking, environmental
Fotios Drakopanagiotakis, Ekaterina Krauss, Ira Michailidou, Vasileios Drosos, Stavros Anevlavis, Andreas Günther, Paschalis Steiropoulos   +6 more
openaire   +2 more sources