Results 81 to 90 of about 1,106,073 (318)

Integrated Bayesian approach to incorporate prior biological knowledge in the investigation of genetic variants associated with lung function [PDF]

, 2018
Genetic association studies aim to identify single-nucleotide polymorphisms (SNPs) that are associated with complex diseases and traits. These studies, especially those performed at the genome-wide level, have successfully identified many SNPs associated
Pereira, M
core   +1 more source

Future Prospects and Challenges in Targeting Cellular and Molecular Mechanisms in Respiratory Diseases [PDF]

, 2023
Respiratory disease is a global health issue causing increased death rate. Significant research has been done in understanding the fundamental mechanism of lung disease for managing patient’s health with a range of respiratory diseases.
Dua, K, Verma, N, Thapa, K
core   +1 more source

Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis

Respiratory Research, 2022
Background Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD), including a few with sarcoidosis.
M. C. Schimmelpennink, D. B. Meek, A. D. M. Vorselaars, L. C. M. Langezaal, C. H. M. van Moorsel, J. J. van der Vis, M. Veltkamp, J. C. Grutters   +7 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

MARCKS and Lung Disease [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2019
Abstract MARCKS (myristoylated alanine-rich C kinase substrate) is a prominent PKC substrate expressed in all eukaryotic cells. It is known to bind to and cross-link actin filaments, to serve as a bridge between Ca2+/calmodulin and PKC signaling, and to sequester the signaling molecule phosphatidylinositol 4,5-bisphosphate in the ...
Mary K, Sheats, Qi, Yin, Shijing, Fang, Joungjoa, Park, Anne L, Crews, Indu, Parikh, Brian, Dickson, Kenneth B, Adler   +7 more
openaire   +2 more sources

Lung function in the general population : the complex interplay of variants in "Serpina1" and other genes with the environment [PDF]

, 2013
Background. One of the globally most frequent health problems are obstructive lung diseases such as asthma and chronic obstructive pulmonary disease.
Thun, Gian Andri
core   +1 more source

RT-PCR Misdiagnosis of Patient with Rare EGFR Mutation Lung Adenocarcinoma: Is NGS the Only Solution?

Diagnostics
Background and Clinical Significance: Molecular testing plays a crucial role in lung cancer diagnosis and management. While single-gene tests (SGTs) remain an important diagnostic tool, developments in novel methods such as next generation sequencing ...
Piotr Piekarczyk, Urszula Lechowicz, Janusz Szopiński, Mateusz Polaczek, Katarzyna Błasińska, Katarzyna Modrzewska   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis

Respiratory Research, 2020
Background Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase, clinical phenotypes, disease ...
David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, Miriana d’Alessandro, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli, Paola Rottoli   +14 more
doaj   +1 more source