Results 101 to 110 of about 1,106,073 (318)
Interstitial lung disease and connective tissue diseases [PDF]
, 2016 Lung involvement in rheumatologic diseases has a broad spectrum of clinical and radiological presentations, from acute inflammatory to chronic, fibrosing predominance.
Geiser, Thomas, Guler, Sabina
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Reference values of impulse oscillometric lung function indices in adults of advanced age. [PDF]
, 2013 Impulse oscillometry (IOS) is a non-demanding lung function test. Its diagnostic use may be particularly useful in patients of advanced age with physical or mental limitations unable to perform spirometry.
Wichmann, Heinz-Erich +53 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A common microbial signature is present in the lower airways of interstitial lung diseases including sarcoidosis [PDF]
, 2018 Background: The etiology of pulmonary sarcoidosis is not well established. Although the mechanism triggering pulmonary sarcoidosis remains to be established, inflammatory reactions seem to play an important role in this process.
Bocchino, Marialuisa +6 more
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
The burden of lung disease [PDF]
Thorax, 2006 A timely reminder of the needs of people with respiratory disease in the UK The range of clinical conditions included under the umbrella of “respiratory medicine” is wide. From cancers to obstructive sleep apnoea, interstitial lung disease to airways disease, occupational lung disease to respiratory infections, there is a variety present in ...
openaire +2 more sources
Interstitial Lung Diseases and Non-Small Cell Lung Cancer: Particularities in Pathogenesis and Expression of Driver Mutations [PDF]
Introduction: Interstitial lung diseases are a varied group of diseases associated with chronic inflammation and fibrosis. With the emerging and current treatment options, survival rates have vastly improved.
Foteinos-Ioannis Dimitrakopoulos +5 more
core +1 more source
Pulmonary hypertension associated with chronic lung diseases [PDF]
, 2016 In 2015, the international guidelines for diagnosis and treatment of pulmonary hypertension (PH) were updated. Group 3 of the current classification includes PH associated with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD),
Otto D. Schoch +5 more
core +1 more source