Results 101 to 110 of about 3,911,704 (314)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities [PDF]

, 2012
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary
Grobusch, Martin P., Pletschette, Michel, Mchugh, Timothy D., Schwank, Samana, Zumla, A, McNerney, R., Squire, S. Bertel, Ford, Nathan, Kim, P.S., Marais, B, Squire, S B, Migliori, Giovanni Batista, Bates, M, McHugh, Timothy D, Grobusch, M.P., McNerney, R, Migliori, G-B, Migliori, Giovanni-Batista, Squire, Bertie, Lawn, S, O'Grady, J, Chakaya, J., Lawn, Steve, Mwaba, Peter, Harari, Alexandre, Memish, Z, Harari, A., Cox, Helen, Abubakar, I, Ford, N, Hoelscher, Michael, Chakaya, J, Kim, Peter, Zijenah, L, Casenghi, M., Grobusch, M P, Casenghi, Martina, McHugh, T D, Marais, B., Weyer, K., Pantaleo, Giuseppe, Schito, Marco, Pletschette, M, Abubakar, Ibrahim, Atun, Rifat, Weyer, K, Mchugh, Timothy, O'Grady, J., Schwank, S, Mwaba, P., Grobusch, Martin P, Mwaba, P, Casenghi, M, Lawn, S., Squire, S, Zijenah, L., Ditui, Lucica, Cox, H., Pantaleo, G, Kim, P S, Schito, M, Weyer, Karin, O'Grady, Justin, Atun, R, Kim, Peter S, Harari, A, Grobusch, Martin, Abubakar, I., Zijenah, Lynn, Bates, Matthew, Memish, Ziad, Cox, H, Pletschette, M., Memish, Z., Schwank, S., Squire, S Bertel, Migliori, G.B., Ditui, L., McNerney, Ruth, Hoelscher, M., McHugh, T.D., Bates, M., Swaminathan, Soumya, Marais, Ben, Maeurer, Markus, Pantaleo, G., Zumla, A., Maeurer, M, Swaminathan, S, Kim, Peter S., Ditui, L, Hoelscher, M, Squire, S.B., Chakaya, Jeremiah, Ford, N., Zumla, Alimuddin, Schito, M., Maeurer, M., Swaminathan, S., Atun, R., Grobusch, MP, Mchugh, TD, Chakaya,, J et. al, Maeurer, M,   +103 more
core   +1 more source

The burden of lung disease [PDF]

Thorax, 2006
A timely reminder of the needs of people with respiratory disease in the UK The range of clinical conditions included under the umbrella of “respiratory medicine” is wide. From cancers to obstructive sleep apnoea, interstitial lung disease to airways disease, occupational lung disease to respiratory infections, there is a variety present in ...
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The impact of the war in Ukraine on the prevalence of MDR/RR-TB in Poland

IJTLD Open
BACKGROUND: The 2022 invasion of Ukraine by the Russian Federation triggered a refugee crisis, affecting the multidrug-/rifampicin-resistant TB (MDR/RR-TB) prevalence in neighbouring countries.
A. Nowinski, E. Augustynowicz-Kopeć, J. Garnczarek, A. Halicka, M. Koszela, W. Litwiniuk, D. Maj, I. Mazur, J. Niestrój-Ostrowska, R. Podlasin, A. Regulska, M. Wielopolska, J. Wyrwiński, S. Wesołowski, M. Korzeniewska-Koseła   +14 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Is There Any Point in a Corticosteroid Treatment of Intermittent Asthma?

The Scientific World Journal, 2007
International guidelines advocate the early introduction of inhaled corticosteroids (ICS) in all types of persistent asthma. Our study was undertaken to assess the effects of ICS on bronchial hyperresponsiveness (BHR) as a hallmark of inflammation, and ...
Ivana Stankovic, Tatjana Pejcic, Branislava Milenkovic, Dragana Jovanovic, Milan Rancic   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Management Challenges and Outcomes of Bronchiolitis Obliterans Syndrome After Hematopoietic Stem Cell Transplantation: First Case Series Report From Vietnam

Case Reports in Hematology
Bronchiolitis obliterans syndrome (BOS) is a serious pulmonary manifestation of chronic graft-versus-host disease (cGvHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Data from low- and middle-income countries remain scarce.
Luong Dinh-Van, Hoang-Anh Nguyen-Cong, Nguyen Tran-Ngoc, Bich-Ngoc T. Nguyen   +3 more
doaj   +1 more source