Results 111 to 120 of about 3,911,704 (314)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A common microbial signature is present in the lower airways of interstitial lung diseases including sarcoidosis [PDF]

, 2018
Background: The etiology of pulmonary sarcoidosis is not well established. Although the mechanism triggering pulmonary sarcoidosis remains to be established, inflammatory reactions seem to play an important role in this process.
Bocchino, Marialuisa, MOCCIA, LIVIO GIOACCHINO, Precone, Vincenza, Postiglione, Irene, Casaburi, Giorgio, Sanduzzi, Alessandro, D'Argenio, Valeria   +6 more
core  

Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: results of a prospective, randomized international trial in lung transplantation.

, 2012
Chronic lung allograft dysfunction, which manifests as bronchiolitis obliterans syndrome (BOS), is recognized as the primary cause of morbidity and mortality after lung transplantation.
Klepetko, Walter, European and Australian Investigators in Lung Transplantation, Glanville, A.R., Aubert, John-David, Knoop, C., Vettorazzi, Eik, Aubert, J.D., Aboyoun, Christina, Klepetko, W., Vettorazzi, E., Reichenspurner, H., Reichenspurner, Hermann, Treede, Hendrik, Glanville, Allan R., Knoop, Christiane, Bravo, Carlos, Lama, Raffael, Lama, R., European,, Aboyoun, C., Bravo, C., Treede, H.   +21 more
core   +1 more source

Estimating The Annual Cost of Smoking-Related Diseases in Indonesia [PDF]

, 2009
Background: Smoking plays a role in the development of chronic diseases and causes substantial negative economic consequences. This study was carried out to estimate the annual cost of smoking-related cardio-cerebrovascular and pulmonary diseases in ...
Hudoyo, Ahmad, Purwaningsih, Endang, Surtidewi, Lujna, Sutrisna, Bambang, Jusuf, Anwar, Kusmana, Dede, Setianto, Budhi   +6 more
core   +1 more source

Lung Diseases in the Elderly [PDF]

Respiration, 1998
Accessible online at: http://BioMedNet.com/karger In the present issue of Respiration, Quadrelli and Roncoroni [1] compare characteristics of asthma between 99 younger patients and 50 elderly asthmatics. Their results suggest that the severity of asthma increases with age and that the increase in severity is related to the duration of the disease ...
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Reference values of impulse oscillometric lung function indices in adults of advanced age. [PDF]

, 2013
Impulse oscillometry (IOS) is a non-demanding lung function test. Its diagnostic use may be particularly useful in patients of advanced age with physical or mental limitations unable to perform spirometry.
Wichmann, Heinz-Erich, Rudolf A. Jörres, Margit Heier, Rudolf A. Jörres (340115), Behr, Jürgen, Holle, R., H.-Erich Wichmann (72009), H.-Erich Wichmann, Karrasch, S., Huber, R.M., Wichmann, H.-E., Rolf Holle, Rudolf M. Huber (412835), Nowak, Dennis, Peters, Annette, Joachim Heinrich (60421), Stefan Karrasch, Rudolf A Jörres, Rolf Holle (262610), KORA Study Group, Annette Peters (62601), Schulz, H., Holle, Rolf, Heier, M., Karrasch, Stefan, Annette Peters, Jürgen Behr (272687), Nowak, D., Holger Schulz, Dennis Nowak, Schulz, Holger, Peters, A., Huber, Rudolf M., Joachim Heinrich, Claudia Flexeder, Heinrich, Joachim, Rudolf M. Huber, H-Erich Wichmann, Claudia Flexeder (412834), Dennis Nowak (412836), Jürgen Behr, Heinrich, J., Rudolf M Huber, Margit Heier (200535), Watz, Henrik, Flexeder, Claudia, Behr, J., Flexeder, C., Stefan Karrasch (412837), Holger Schulz (13022), Jörres, R.A., Heier, Margit, Jörres, Rudolf A., Wichmann, H.-Erich   +53 more
core   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source