Results 31 to 40 of about 12,551,552 (363)

Severe acute respiratory failure due to a multifactorial diffuse alveolar haemorrhage

Respirology Case Reports, 2020
Diffuse alveolar haemorrhage (DAH) is a life‐threatening syndrome caused by infection, coagulation disorders or autoimmune diseases. We here report the case of an 81‐year‐old male subject affected by a multifactorial DAH, in which the bleeding was ...
Ernesto Crisafulli, Barbara Burgazzi, Maria Majori, Walter Serra, Alfredo Chetta   +4 more
doaj   +1 more source

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.

New England Journal of Medicine, 2015
BACKGROUND Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV1) over time.
P. Lange, B. Celli, A. Agustí, Gorm Boje Jensen, M. Divo, R. Faner, S. Guerra, J. Marott, F. Martinez, P. Martínez-Camblor, P. Meek, C. Owen, H. Petersen, V. Pinto-Plata, P. Schnohr, A. Sood, J. Soriano, Y. Tesfaigzi, J. Vestbo   +18 more
semanticscholar   +1 more source

SARS-CoV-2 infection of hACE2 transgenic mice causes severe lung inflammation and impaired function

Nature Immunology, 2020
Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease phenotypes seen in humans who have been hospitalized.
Emma S. Winkler, Adam Leitman Bailey, Natasha M. Kafai, S. Nair, B. McCune, Jinsheng Yu, J. Fox, Rita E. Chen, J. T. Earnest, Shamus P. Keeler, J. Ritter, L. Kang, Sarah Dort, A. Robichaud, R. Head, M. Holtzman, M. Diamond   +16 more
semanticscholar   +1 more source

Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains

Frontiers in Physiology, 2018
Introduction: We investigated the effect of partial mechanical unloading (PMU) of the heart on the physiology of calcium and beta-adrenoceptor-cAMP (βAR-cAMP) microdomains.
Peter T. Wright, Jose L. Sanchez-Alonso, Carla Lucarelli, Carla Lucarelli, Anita Alvarez-Laviada, Claire E. Poulet, Sean O. Bello, Giuseppe Faggian, Cesare M. Terracciano, Julia Gorelik   +9 more
doaj   +1 more source

Ultrasound evaluation of diaphragmatic function in patients with idiopathic pulmonary fibrosis: a retrospective observational study

Respiratory Research, 2023
Introduction The diaphragm function assessed by ultrasound has been well-studied in COPD, asthma, and intensive care. However, there are only a few studies on diffuse interstitial lung disease, while dyspnea and quality of life are major issues in the ...
Jules Milesi, Alain Boussuges, Paul Habert, Julien Bermudez, Martine Reynaud-Gaubert, Stéphane Delliaux, Fabienne Bregeon, Benjamin Coiffard   +7 more
doaj   +1 more source

Regulation of Immunoproteasome Function in the Lung [PDF]

Scientific Reports, 2015
AbstractImpaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8+  T cells that are activated by MHC I-mediated presentation of pathogen-derived ...
Keller, I.E., Vosyka, O., Takenaka, S., Kloss, A., Dahlmann, B., Willems, L.I., Verdoes, M., Overkleeft, H.S., Marcos, E., Adnot, S., Hauck, S.M., Ruppert, C., Guenther, A., Herold, S., Ohno, S., Adler, H., Eickelberg, O., Meiners, S.   +17 more
openaire   +8 more sources

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

Nature Communications, 2018
PI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted ...
C. C. Campa, R. L. Silva, J. P. Margaria, T. Pirali, M. Mattos, L. Kraemer, D. C. Reis, G. Grosa, Francesca Copperi, E. Dalmarco, R. Lima-Júnior, S. Aprile, V. Sala, F. Dal Bello, D. Prado, J. Alves-Filho, C. Medana, G. Cassali, G. Tron, M. Teixeira, E. Ciraolo, R. C. Russo, E. Hirsch   +22 more
semanticscholar   +1 more source

SARS-CoV-2 Neutralizing Antibodies: A Network Meta-Analysis across Vaccines

Vaccines, 2021
Background: There are no studies providing head-to-head comparison across SARS-CoV-2 vaccines. Therefore, we compared the efficacy of candidate vaccines in inducing neutralizing antibodies against SARS-CoV-2.
Paola Rogliani, Alfredo Chetta, Mario Cazzola, Luigino Calzetta   +3 more
doaj   +1 more source

Lung function in the elderly. [PDF]

Thorax, 1985
Data are presented on the FEV1 and forced vital capacity (FVC) of elderly people living at home. These were derived from a survey of 418 persons over the age of 70 years and thus provide standards for the assessment of elderly persons. There was a decline in FEV1 and FVC cross sectionally with age and a continued adverse effect of smoking. A history of
K. M. Phillips, Michael Leslie Burr, D. N. Hurst   +2 more
openaire   +3 more sources

Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2018
Electronic cigarettes (e-cigs) are advertised as a less harmful nicotine delivery system or as a new smoking cessation tool. We aimed to assess the in vivo effects of e-cig vapor in the lung and to compare them to those of cigarette smoke (CS).
C. Glynos, Sofia-Iris Bibli, P. Katsaounou, A. Pavlidou, Christina Magkou, V. Karavana, Stavros Topouzis, Ioannis Kalomenidis, S. Zakynthinos, A. Papapetropoulos   +9 more
semanticscholar   +1 more source