Results 31 to 40 of about 1,734,155 (309)

Long-term effects of allergen sensitization and exposure in adult asthma: a prospective study. [PDF]

, 2009
BACKGROUND: : We investigated the effects of sensitization and exposure to common domestic allergens on longitudinal changes in lung function and bronchial hyperresponsiveness. METHODS: : Subjects attended 2 visits that were 4 years apart.
Adnan Custovic, Angela Simpson, Antens, Ashley Woodcock, Asokananthan, Barter, Braun-Fahrlander, Chapman, Dijkstra, Fowler, Gehring, Gore, Grol, Juniper, Kharitonov, Lange, Langley, Langley, Luczynska, Masoli, Nicholas J. Truman, Salome, Schou, Simpson, Stephen J. Fowler, Stephen J. Langley, Taylor, Thorne, Vonk, Waser, Yan   +30 more
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Lung Function Testing [PDF]

, 2005
Although diagnosis always begins with a careful history and physical examination and a physician is obligated to consider more than the diseased organ, testing of lung function has become standard practice to confirm the diagnosis, evaluate the severity of respiratory impairment, assess the therapy response and follow-up patients with various cardio ...
H. Stam, R. Gosselink
openaire   +3 more sources

Lung Development Genes and Adult Lung Function

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Poor lung health in adult life may occur partly through suboptimal growth and development, as suggested by epidemiological evidence pointing to early life risk factors.Objectives: To systematically investigate the effects of lung development genes on adult lung function.Methods: Using UK Biobank data, we tested the association of 391 genes ...
Seif O. Shaheen, Charlotte H. Dean, Miguel Pereira, Matthew Hind, Matthew Hind, Peter Burney, Annah B. Wyss, Cosetta Minelli, Stephanie J. London, Laura Portas   +9 more
openaire   +5 more sources

The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver [PDF]

, 1991
Plasma FK506 was studied in 49 liver, 13 heart, 3 double-lung or heart-lung, and 21 kidney recipients. The levels were correlated with the drug doses used, kidney function, and liver function.
Abu-Elmagd, K, Alessiani, M, Fung, JJ, Jain, A, Shannon, WD, Starzl, TE, Takaya, S, Todo, S, Venkataramanan, R, Warty, VS   +9 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Vitamin A and lung function in CF [PDF]

Journal of Cystic Fibrosis, 2006
Laboratory evidence suggests that vitamin A could have a protective effect on respiratory status in patients with cystic fibrosis (CF). This study shows a significant correlation between serum vitamin A concentrations and every aspect of lung function tested in 38 patients with stable CF.
Aird, Fiona K., Greene, Stephen A., Ogston, Simon A., Macdonald, Thomas M., Mukhopadhyay, Somnath   +4 more
openaire   +4 more sources

Extraction of reliable information from time-domain pressure and flow signals measured by means of forced oscillation techniques [PDF]

, 2014
This paper aims to give a proof-of-concept for the possible application of the forced oscillation lung function test to assess the viscoelastic properties of the airways and tissue.
Baleanu, Dumitru, Ionescu, Clara-Mihaela, Nigmatullin, Raoul R, Osokin, Serghei I   +3 more
core   +1 more source

Role of small colony variants in persistence of Pseudomonas aeruginosa infections in cystic fibrosis lungs [PDF]

, 2015
Jacob G Malone1,21John Innes Centre, Norwich, UK; 2School of Biological Sciences, University of East Anglia, Norwich, UKAbstract: Pseudomonas aeruginosa is an opportunistic pathogen that predominates during the later stages of cystic fibrosis (CF) lung ...
Malone, Jacob
core   +2 more sources