Results 71 to 80 of about 1,947,503 (351)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Functional vascularized lung grafts for lung bioengineering [PDF]

Science Advances, 2017
We propose a new approach to lung regeneration by replacement of damaged epithelium with full preservation of lung vasculature.
N. Valerio Dorrello, Brandon A. Guenthart, John D. O’Neill, Jinho Kim, Katherine Cunningham, Ya-Wen Chen, Mauer Biscotti, Theresa Swayne, Holly M. Wobma, Sarah X. L. Huang, Hans-Willem Snoeck, Matthew Bacchetta, Gordana Vunjak-Novakovic   +12 more
openaire   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts

Cell Reports, 2018
Summary: Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy.
Peter T. Wright, Navneet K. Bhogal, Ivan Diakonov, Laura M.K. Pannell, Ruwan K. Perera, Nadja I. Bork, Sophie Schobesberger, Carla Lucarelli, Giuseppe Faggian, Anita Alvarez-Laviada, Manuela Zaccolo, Timothy J. Kamp, Ravi C. Balijepalli, Alexander R. Lyon, Sian E. Harding, Viacheslav O. Nikolaev, Julia Gorelik   +16 more
doaj   +1 more source

A semi-parametric approach to estimate risk functions associated with multi-dimensional exposure profiles: application to smoking and lung cancer [PDF]

, 2013
A common characteristic of environmental epidemiology is the multi-dimensional aspect of exposure patterns, frequently reduced to a cumulative exposure for simplicity of analysis.
A Lacourt, AE Gelfand, B Pesch, C Tarnaud, CE Antoniak, D Consonni, D Dahl, D Luce, David I Hastie, DI Ohlssen, H Ishwaran, H Ishwaran, H Ishwaran, H Zhang, Isabelle Stücker, J Molitor, J Peto, JH Lubin, JH Lubin, JS Liu, L Breiman, L Kaufman, Lamiae Azizi, M Abrahamowicz, M Kalli, M Papathomas, M Papathomas, MD Ritchie, P Papaspiliopoulos, PJ Green, R Goel, R Peto, RF MacLehose, SC Lemon, SG Walker, Silvia Liverani, SW Thurston, Sylvia Richardson, W Wang   +38 more
core   +5 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline [PDF]

, 2017
Background: Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be ...
Abecasis, Afzal, Alan James, American Thoracic Society, American Thoracic Society, Anders Malarstig, Arthur W Musk, Børge G Nordestgaard, Castaldi, Catherine John, Cho, Collins, Curjuric, DeMeo, Devlin, Fletcher, Gottlieb, Hancock, Hansel, Hole, Howie, Iain Kilty, Ian P Hall, Imboden, James, James, James, Jennie Hui, John Beilby, Kathleen Barnes, Lange, Li, Liao, Loth, Louise V Wain, Martin D Tobin, María Soler Artigas, Nadia N Hansel, Nicholas Rafaels, Nick Shrine, Patterson, Peter D Paré, Pillai, Price, Purcell, Repapi, Ryan, Schnohr, Schunemann, Scott A Jelinsky, Signe Vedel-Krogh, Soler Artigas, Soler Artigas, Sune Fallgaard Nielsen, Tang, Thun, Wilk, Wilk   +57 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Evaluation of computed tomography in the diagnosis of ultrasound-proven diaphragm dysfunction

Respiratory Research
Introduction Computed tomography (CT) is routinely employed on the evaluation of dyspnea, yet limited data exist on its assessment of diaphragmatic muscle.
Pauline Lallement, Alain Boussuges, Paul Habert, Julien Bermudez, Martine Reynaud-Gaubert, Stéphane Delliaux, Fabienne Bregeon, Benjamin Coiffard   +7 more
doaj   +1 more source

Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD

International Journal of Endocrinology, 2012
In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli.
Alfredo Chetta, Dario Olivieri
doaj   +1 more source