Results 21 to 30 of about 877,566 (357)
EBioMedicine, 2016 Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown.
Jing Zhao +6 more
doaj +1 more source
Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
Frontiers in Immunology, 2021 The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized.
Hernán F. Peñaloza +5 more
doaj +1 more source
RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity
eLife, 2016 Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through ...
Alison C McKelvey +9 more
doaj +1 more source
Journal of Immunology Research, 2015 Interleukin- (IL-) 22 signaling is protective in animal models of pneumonia and bacteremia by Klebsiella pneumoniae and mediates tissue recovery from influenza and Staph aureus infection.
Joseph Franz +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest +19 more
doaj +1 more source
Cell Reports, 2014 Summary: Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generated by
Bill B. Chen +19 more
doaj +1 more source
A fresh look at paralytics in the critically ill: real promise and real concern. [PDF]
, 2012 Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails.
Kenyon, Nicholas J +2 more
core +2 more sources
Vaping-associated Lung Injury [PDF]
Cureus, 2019 Many cases related to vaping-associated lung injury have recently been reported to the Center for Disease Control (CDC). It is, therefore, important for clinicians to be aware of this disease. Here, we present the case of a 46-year-old female patient, who had recently started vaping.
Aftab, Ghulam +2 more
openaire +4 more sources
The role of ubiquitination and deubiquitination in the regulation of cell junctions
Protein & Cell, 2017 Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death.
Junting Cai +3 more
doaj +1 more source
protection by adrenomedullin [PDF]
, 2014 Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide
Gruber, Achim Dieter +13 more
core +1 more source