Results 41 to 50 of about 42,166 (258)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comparing lung mechanics of patients with COVID related respiratory distress syndrome versus non-COVID acute respiratory distress syndrome: a retrospective observational study

Journal of Mechanical Ventilation, 2022
Background Most patients admitted to the intensive care unit with coronavirus disease (COVID-19) develop severe respiratory failure. Understanding lung mechanics helps to guide protective mechanical ventilation, improve oxygenation, and reduce the ...
Francisco Chacón-Lozsán, Péter Tamási   +1 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of Recruitment Maneuvers on Oxygen Saturation, End Tidal Carbon Dioxide and Lung Mechanics in Pressure Control Ventilation Versus Volume Control Ventilation for Patient Undergoing Laparoscopic Sleeve Gastrectomy

مجلة كلية الطب, 2013
Background: Atelectasis occurs regularly after induction of general anesthesia in bariatric surgery, persists postoperatively, and may contribute to significant postoperative morbidity.
Sabah N. Al Saad
doaj   +1 more source

Compensatory lung growth after bilobectomy in emphysematous rats. [PDF]

PLoS ONE, 2017
Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes.
Francine Maria Almeida, Beatriz Mangueira Saraiva-Romanholo, Rodolfo Paula Vieira, Henrique Takachi Moriya, Ana Paula Ligeiro-de-Oliveira, Fernanda Dtqs Lopes, Hugo C Castro-Faria-Neto, Thais Mauad, Milton Arruda Martins, Rogerio Pazetti   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The relationship between exercise capacity and different functional markers in pulmonary rehabilitation for COPD

International Journal of COPD, 2018
Maria Kerti, Zsuzsanna Balogh, Krisztina Kelemen, Janos T Varga Department of Pulmonary Rehabilitation, National Koranyi Institute for Pulmonology, Budapest, Hungary Rationale: The relationship of functional parameters such as lung mechanics, chest ...
Kerti M, Balogh Z, Kelemen K, Varga JT
doaj  

Integrating ultra-prolonged prone ventilation with mechanical power monitoring in refractory acute respiratory distress syndrome (ARDS): a case report

Frontiers in Medicine
IntroductionAcute respiratory distress syndrome (ARDS) manifests as acute pulmonary inflammation associated with high mortality. While intermittent prone positioning for 12–16 h is an essential intervention in managing severe ARDS, clinical challenges ...
Ting-Li Zhuang, Ting-Li Zhuang, Shih-Heng Lin, Dong-En Chuang, Han-Lin Hsu, Wan-Wen Huang, Hao Hsieh, Xiao-Yue Chen, Xiao-Yue Chen   +8 more
doaj   +1 more source

Intracranial pressure responsiveness to positive end-expiratory pressure in different respiratory mechanics: a preliminary experimental study in pigs

BMC Neurology, 2018
Background Respiratory mechanics affects the effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP). Respiratory mechanics of the lung and the chest wall was not differentiated in previous studies.
Han Chen, Jing Zhou, Yi-Qin Lin, Jian-Xin Zhou, Rong-Guo Yu   +4 more
doaj   +1 more source