Results 31 to 40 of about 42,166 (258)

Moderate aerobic training improves cardiorespiratory parameters in elastase-induced emphysema

Frontiers in Physiology, 2016
Aim: We investigated the therapeutic effects of aerobic training on lung mechanics, inflammation, morphometry and biological markers associated with inflammation and endothelial cell damage, as well as cardiac function in a model of elastase-induced ...
Isabela Henriques, Miquéias Lopes-Pacheco, Miquéias Lopes-Pacheco, Gisele De Araujo Padilha, Patrícia S. Marques, Raquel F. Magalhães, Mariana A. Antunes, Marcelo Marcos Morales, Nazareth N. Rocha, Nazareth N. Rocha, Pedro Leme Silva, Debora Goncalves Xisto, Patricia Rieken Macedo Rocco   +12 more
doaj   +1 more source

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

Frontiers in Physics, 2023
Cardiac mechanics models are developed to represent a high level of detail, including refined anatomies, accurate cell mechanics models, and platforms to link microscale physiology to whole-organ function.
Cristobal Rodero, Tiffany M. G. Baptiste, Tiffany M. G. Baptiste, Rosie K. Barrows, Rosie K. Barrows, Alexandre Lewalle, Steven A. Niederer, Steven A. Niederer, Marina Strocchi   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Assessment of murine lung mechanics outcome measures: alignment with those made in asthmatics

Frontiers in Physiology, 2013
Although asthma is characterized as an inflammatory disease, recent reports highlight the importance of pulmonary physiology outcome measures to the clinical assessment of asthma control and risk of asthma exacerbation.
Julia Kathleen Louise Walker, Monica eKraft, John T Fisher   +2 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreases lung elastance

Frontiers in Physiology, 2012
Exposure to second hand tobacco smoke is associated with the development and/or exacerbation of several different pulmonary diseases in humans. To better understand the possible effects of second hand smoke exposure in humans, we sub-chronically (4 weeks)
John M. Hartney, Hong Wei eChu, Roberta ePelanda, Raul M Torres   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Small Airway Dysfunction in Chronic Obstructive Pulmonary Disease Pathology: Assessment and Clinical Implications [PDF]

Tuberculosis and Respiratory Diseases
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by airflow limitation and persistent respiratory symptoms. A key factor in the progression of COPD is small airway dysfunction (SAD), which originates in airways ...
Jong Geol Jang, Hyonsoo Joo, Hyun Lee
doaj   +1 more source

Combined effects of ventilation mode and positive end-expiratory pressure on mechanics, gas exchange and the epithelium in mice with acute lung injury. [PDF]

PLoS ONE, 2013
The accepted protocol to ventilate patients with acute lung injury is to use low tidal volume (V(T)) in combination with recruitment maneuvers or positive end-expiratory pressure (PEEP). However, an important aspect of mechanical ventilation has not been
Apiradee Thammanomai, Hiroshi Hamakawa, Erzsébet Bartolák-Suki, Béla Suki   +3 more
doaj   +1 more source