Results 21 to 30 of about 42,166 (258)
Lung analysis in children mechanically ventilated with atelectasis after cardiac surgery
Fisioterapia e Pesquisa, 2015 The main objective of this study is to associate the healthy area of the lung (evaluated by radiography) with the data of respiratory mechanics in children with atelectasis after cardiac surgery, under mechanical ventilation in the assisted controlled ...
Adriane Muller Nakato +4 more
doaj +1 more source
PLoS ONE, 2022 BackgroundNon-invasive ventilation (NIV) has been increasingly used in COVID-19 patients. The limited physiological monitoring and the unavailability of respiratory mechanic measures, usually obtainable during invasive ventilation, is a limitation of NIV
Chiara Torregiani +7 more
doaj +1 more source
2,2'-azobis (2-amidinopropane) dihydrochloride is a useful tool to impair lung function in rats
Frontiers in Physiology, 2016 Recently, several studies have reported that respiratory disease may be associated with an increased production of free radicals. In this context, 2,2’-azobis (2-amidinopropane) dihydrochloride (AAPH) is a free radical-generating compound widely used to ...
Maria Diana Moreira-Gomes +7 more
doaj +1 more source
Frontiers in Physiology, 2019 Chronic obstructive pulmonary disease (COPD) is a progressive disorder of the lung parenchyma which also involves extrapulmonary manifestations, such as cardiovascular impairment, diaphragm dysfunction, and frequent exacerbations.
Milena Vasconcellos de Oliveira +12 more
doaj +1 more source
Respiratory Medicine Case Reports, 2023 Understanding of pulmonary mechanics is essential to understanding mechanical ventilation. Typically, clinicians are mindful of peak and plateau pressures displayed on the ventilator and lung compliance, which is decreased in lung disease such as ...
Shameek Gayen +3 more
doaj +1 more source
Pharmaceutics, 2021 Aerosol therapy in patients suffering from acute respiratory distress syndrome (ARDS) has so far failed in improving patients’ outcomes. This might be because dependent lung areas cannot be reached by conventional aerosols.
Matthias Otto +7 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Quantification of Age‐Related Lung Tissue Mechanics under Mechanical Ventilation
Medical Sciences, 2017 Elderly patients with obstructive lung diseases often receive mechanical ventilation to support their breathing and restore respiratory function. However, mechanical ventilation is known to increase the severity of ventilator‐induced lung injury (VILI ...
JongWon Kim +3 more
doaj +1 more source
Recurrent recruitment manoeuvres improve lung mechanics and minimize lung injury during mechanical ventilation of healthy mice. [PDF]
PLoS ONE, 2011 INTRODUCTION: Mechanical ventilation (MV) of mice is increasingly required in experimental studies, but the conditions that allow stable ventilation of mice over several hours have not yet been fully defined. In addition, most previous studies documented
Lucy Kathleen Reiss +2 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source