A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. [PDF]
PLoS ONE, 2014 PURPOSE:To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung tumors. Tumor blood volume and vascular permeability were quantified using gold and iodine
Jeffrey R Ashton +6 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Does Global Lung Initiative Obviate the Need for Lung Volume Measurements? [PDF]
Respiratory Care, 2017 Establishing the diagnosis of restrictive lung disease is often difficult and requires extensive testing not only to diagnose but also to accurately classify the underlying disease. Current clinical practice often involves an initial screening with spirometry and a subsequent measurement of ...
Amaya D, George, Andrew J, Skabelund
openaire +2 more sources
National Journal of Medical Research, 2012 Background: People with Spinal Cord Injury (SCI) frequently experience various complications. Subjects with SCI are in a sitting posture for prolonged periods of time, it is important to know how different sitting postures affect pulmonary function ...
Namrata P Prajapati , Anjali R Bhise
doaj
Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images. [PDF]
PLoS ONE, 2013 Computed tomography (CT) is a non-invasive imaging modality used to monitor human lung cancers. Typically, tumor volumes are calculated using manual or semi-automated methods that require substantial user input, and an exponential growth model is used to
Minxing Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Measurement of the Total Lung Volume Using an Adjusted Single-Breath Helium Dilution Method in Patients With Obstructive Lung Disease [PDF]
, 2021 Qing Liu +9 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Functional lung volume measurement method for the prediction of postoperative pulmonary function [PDF]
, 2022 Zheyuan Fan +5 more
openalex +1 more source