Results 91 to 100 of about 2,937 (121)
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British Journal of Haematology, 1987
SummaryThree families having more than one affected member with SLE or lupus‐like disease were investigated by global coagulation tests as well as methods based on dilute thromboplastin, Russell's viper venom and thermal stability/absorption, and by RIA for anticardiolipin (CL) antibodies. Of the 19 persons, 11 had SLE or lupus‐like disease.
IJ Mackie, CB Colaco, SJ Machin
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SummaryThree families having more than one affected member with SLE or lupus‐like disease were investigated by global coagulation tests as well as methods based on dilute thromboplastin, Russell's viper venom and thermal stability/absorption, and by RIA for anticardiolipin (CL) antibodies. Of the 19 persons, 11 had SLE or lupus‐like disease.
IJ Mackie, CB Colaco, SJ Machin
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The Lupus Anticoagulant Paradox
Seminars in Thrombosis and Hemostasis, 2017AbstractLupus anticoagulant (LA) represents the most enigmatic antibody population in patients with antiphospholipid syndrome and represents a paradox that is still unsolved. This class of antiphospholipid antibody causes a phospholipid-dependent prolongation of the clotting time but is associated with an increased risk of thrombosis and pregnancy ...
Rolf T. Urbanus +2 more
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Cofactor of the “Lupus Anticoagulant”
Thrombosis and Haemostasis, 1974SummaryNormal plasma contains an activity known as cofactor which further lengthens the clotting time of the plasma of some patients with the “lupus anticoagulant.55 Cofactor has been characterized as either prothrombin or a gamma globulin. Our findings indicate that cofactor has the following properties: stable at room temperature but largely ...
Sandra Schiffman +2 more
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Familial Association of the Lupus Anticoagulant [PDF]
British Journal of Haematology, 1980 Summary. A lupus anticoagulant was detected in plasma from two pairs of siblings using the kaolin clotting time mixing test. Strong evidence for this inhibitor in one further sibling pair is presented. Although coagulation abnormalities are usually classified as either acquired or of genetic origin it is apparent that the lupus anticoagulant might ...
S. Barber +3 more
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Neurology and the Lupus Anticoagulant
European Neurology, 1985The lupus anticoagulant, an immunoglobulin of the IgG or IgM class, is one of a group of antiphospholipid antibodies. Although an anticoagulant in vitro, its action in vivo is that of a procoagulant. This procoagulant activity may involve many organ systems including the nervous system.
G. R. V. Hughes +2 more
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Testing for Lupus Anticoagulants
Seminars in Thrombosis and Hemostasis, 2022AbstractLupus anticoagulant (LA) is one of the three criteria antiphospholipid antibodies (aPLs) employed in classification, and by default diagnosis, of antiphospholipid syndrome (APS). Detection of LA is not via calibrated assays but is based on functional behavior of the antibodies in a medley of coagulation assays.
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Standardization of lupus anticoagulant. The Lupus Anticoagulant Sensitivity Index (LASI)
Lupus, 2012Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (PatientClotting time/NormalClotting time). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-laboratory comparison of results.
Tripodi A +2 more
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Lupus anticoagulants in children
Current Opinion in Hematology, 2003Lupus anticoagulant and ACAs are made up of heterogeneous IgG and IgM antibodies that prolong in vitro clotting times and are associated with increased risks of venous and arterial thrombosis, recurrent fetal loss, and autoimmune thrombocytopenia and anemia.
Thomas C. Abshire, Michael Briones
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Lupus-Anticoagulant in der Schwangerschaft
Geburtshilfe und Frauenheilkunde, 1986The case of a patient with recurrent abortions and one premature deficient birth is described. The underlying condition was an immunocoagulopathy caused by a lupus anticoagulant, leading to a tendency to thrombosis and in pregnancy to abortions, stillbirths, and deficient births. The diagnostic and therapeutic procedure is described and discussed.
Vogel M, Schwerdtfeger R, Kentenich H
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2013
Antiphospholipid antibodies are a heterogenous group of autoantibodies directed against glycoproteins in concert with anionic phospholipids. In clinical laboratory practice, antiphospholipid antibody evaluations usually consist of a combination of the following: anticardiolipin antibody assay, anti-beta 2 glycoprotein I assay, and at least two lupus ...
Karen A. Moffat +2 more
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Antiphospholipid antibodies are a heterogenous group of autoantibodies directed against glycoproteins in concert with anionic phospholipids. In clinical laboratory practice, antiphospholipid antibody evaluations usually consist of a combination of the following: anticardiolipin antibody assay, anti-beta 2 glycoprotein I assay, and at least two lupus ...
Karen A. Moffat +2 more
openaire +3 more sources