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Screening for the lupus anticoagulant
La Ricerca in Clinica e in Laboratorio, 1989The lupus anticoagulant may be defined as an immunoglobulin (IgG, IgM or both) which interferes with one or more of the in vitro phospholipid-dependent tests of coagulation. For many years, lupus anticoagulants were regarded as a laboratory nuisance; consequently, reagents were often selected on the basis of insensitivity to lupus anticoagulants ...
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Lupus anticoagulant and chorea
Neurology, 1997Reply from the Authors: We appreciate Dr. de la Fuente-Fernandez' comments. Our paper suggested that reversible …
Mazen M. Dimachkie +2 more
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Monitoring Anticoagulation Therapy in Patients with the Lupus Anticoagulant
JCR: Journal of Clinical Rheumatology, 1998Patients with a lupus anticoagulant (LAC) may present with thrombosis, and abnormal coagulation studies. It is important to recognize that these individuals may require special laboratory tests other than measuring the activated partial thromboplastin time or prothrombin time/international normalized ratio (PT/INR) traditionally used by clinicians to ...
Kandice Kottke-Marchant +1 more
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Lupus Erythematosus and Lupus Anticoagulant
1990Systemic lupus erythematosus (SLE) occurs primarily in young women, and it often complicates pregnancy. It has been speculated that this autoimmune disorder is so much more common in women than in men (10:1) because of their sensitization to nuclear antigens to which they are exposed during menstruation (Dameshek, 1958; Grimes et al., 1985; Hulka, 1985)
Peter Kaufmann, Kurt Benirschke
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Anticardiolipin Antibodies and the Lupus Anticoagulant
Annals of Internal Medicine, 1987Excerpt To the editor: Petri and colleagues (1) have used the antiphospholipid antibody test inappropriately.
Azzudin E. Gharavi, Michael D. Lockshin
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Procainamide-Induced Lupus Anticoagulant
Southern Medical Journal, 1988The lupus anticoagulant, with or without other symptoms or signs of lupus, has been described in patients taking procainamide. Screening all such patients for the presence of these anticoagulants may be warranted (despite the rarity of episodes of bleeding) in view of the potentially increased risk of thrombotic events in patients who may already be ...
Heyman Mr +3 more
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Mechanisms of activity of lupus anticoagulants
Current Opinion in Hematology, 1997Lupus anticoagulants comprise a heterogenous group of circulating immunoglobulins that are associated with an increased risk of thrombosis. It was believed earlier that these antibodies were directed against anionic phospholipids. Recent findings, however, establish that the autoantibodies in lupus anticoagulants are not directed against "native ...
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Significance of the lupus anticoagulant
American Journal of Hematology, 1986Robert C. Hartmann, Luis R. Espinoza
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Detection of lupus anticoagulants
Clinical Reviews in Allergy & Immunology, 1995M. H. Horellou, M. M. Samama
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