Results 41 to 50 of about 22,001 (226)
Neuropsychiatric lupus erythematosus in a cohort of Egyptian patients
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022 Background The neuropsychiatric lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus (SLE) that is characterized by a variety of neurological manifestations involving both central and peripheral nervous system with ...
Salma M. Ragab, Amira M. Ibrahim
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT RASopathies are clinically overlapping neurodevelopmental syndromes resulting from germline mutations in genes involved in the rat sarcoma/mitogen‐activated protein kinases (RAS/MAPK) pathway. Historically, RASopathies have been described by clinical phenotypes, such as Noonan syndrome and Neurofibromatosis type I.
Anastasia‐Vasiliki Madenidou +6 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito +10 more
wiley +1 more source
Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome
Arthritis &Rheumatology, EarlyView.Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca +13 more
wiley +1 more source
Medicina Universitaria, 2021 Lupus anticoagulant (LA) is a heterogeneous group of antibodies that interfere with phospholipid-dependent coagulation tests, which result in abnormally prolonged clotting times in vitro. The prevalence of LA in a healthy individual is 1-5%1,2.
Luz Tarín-Arzaga +8 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati +13 more
wiley +1 more source
Rapid Disappearance of Lupus Anticoagulant in COVID-19 Infection [PDF]
, 2023 Hyunji Kim +3 more
openalex +1 more source
Arthritis &Rheumatology, EarlyView.Objective To assess the association between early antimalarial adherence and future acute care utilization and cost in a population‐based cohort of incident rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Methods All patients with incident RA/SLE and new antimalarial use in British Columbia, Canada, between January 1997 and March 2022
Md Rashedul Hoque +7 more
wiley +1 more source
Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen +10 more
wiley +1 more source
Frontiers in Immunology, 2022 Multicentric reticulohistiocytosis (MRH) is a rare systemic disease of non-Langerhans cell histiocytosis. A number of studies in the literature have documented that it can coexist with malignancy or autoimmune disease, making it difficult to determine ...
Ziyi Tang +8 more
doaj +1 more source