Lupus anticoagulant-hypoprothrombinemia syndrome with lupus nephritis in a girl misdiagnosed with immunoglobulin A nephropathy: a case report [PDF]
Distinguishing lupus nephritis (LN) from other glomerulopathies, such as immunoglobulin A nephropathy (IgAN), poses a diagnostic challenge owing to overlapping clinical and histopathologic findings. Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS)
Chung Ho Lee+3 more
doaj +1 more source
Reduced Order Optimal Control of the Convective FitzHugh-Nagumo Equation [PDF]
In this paper, we compare three model order reduction methods: the proper orthogonal decomposition (POD), discrete empirical interpolation method (DEIM) and dynamic mode decomposition (DMD) for the optimal control of the convective FitzHugh-Nagumo (FHN) equations.
arxiv +1 more source
Spontaneous bleeding in a patient with malignant lymphoma: A case of acquired hemophilia [PDF]
Background: Acquired hemophilia is a rare condition which can be associated with lymphoproliferative disease. Case Report: Eleven yea rs after the diagnosis of immunocytoma had been made, a 72-year-old man developed a high-titer factor VIII inhibitor. At
Brack, N.+5 more
core +1 more source
International multicenter, multiplatform study to validate Taipan snake venom time as a lupus anticoagulant screening test with ecarin time as the confirmatory test: communication from the ISTH SSC subcommittee on Lupus Anticoagulant/Antiphospholipid antibodies [PDF]
Background Lupus anticoagulant (LA) assays are compromised in anticoagulated patients, and existing strategies to overcome the interferences have limitations.
Devreese, K.+19 more
core +1 more source
microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. [PDF]
BackgroundmicroRNA (miRNA) are important regulators of gene expression. In patients with ischemic stroke we have previously shown that differences in immune cell gene expression are present.
Ander, Bradley P+5 more
core +3 more sources
Gravitoviscous Protoplanetary Discs with a Dust Component. IV. Disc Outer Edges, Spectral Indices, and Opacity Gaps [PDF]
The crucial initial step in planet formation is the agglomeration of micron-sized dust into macroscopic aggregates. This phase is likely to happen very early during the protostellar disc formation, which is characterised by active gas dynamics. We present numerical simulations of protostellar/protoplanetary disc long-term evolution, which includes gas ...
arxiv +1 more source
Concurrent acquired inhibitors to factor VIII and IX, a laboratory artifact: a case report. [PDF]
Acquired inhibitors to coagulation factors other than factor VIII are extremely rare. We describe a case of a 59-year-old woman with abnormal bleeding, diagnosed with concurrent inhibitor antibodies to factor VIII and IX by Bethesda testing.
Andreas Hillarp+5 more
core +2 more sources
Microrheology and structural quantification of hypercoagulable clots [PDF]
We propose a combination of microrheological and structural characterizations of fibrin networks to study blood hypercoagulability. Fibrin is the central element of coagulation as its polymerization creates the network of fibers in which platelets and red blood cells are included.
arxiv
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from G{alpha}12/13 and G{alpha}11/q [PDF]
Increase in vascular permeability occurs under many physiological conditions and is central in diverse human pathologies. Thrombin is a pro-coagulant serine protease, which causes the local loss of endothelial barrier integrity thereby enabling the rapid extravasation of plasma proteins and the local formation of fibrin-containing clots.
arxiv +1 more source
Prediction of recurrent venous thromboembolism by clot lysis time: a prospective cohort study. [PDF]
Venous thromboembolism (VTE) is a chronic disease, which tends to recur. Whether an abnormal fibrinolytic system is associated with an increased risk of VTE is unclear.
Ludwig Traby+4 more
doaj +1 more source