Results 51 to 60 of about 9,990 (166)

36-Year-Old Female with Catastrophic Antiphospholipid Syndrome Treated with Eculizumab: A Case Report and Review of Literature

Case Reports in Hematology, 2014
Catastrophic antiphospholipid syndrome (CAPS) is a rare but potentially life-threatening condition characterized by diffuse vascular thrombosis, leading to multiple organ failure developing over a short period of time in the presence of positive ...
Marianna Strakhan, Mariana Hurtado-Sbordoni, Nahun Galeas, Kamila Bakirhan, Karenza Alexis, Tarek Elrafei   +5 more
doaj   +1 more source

The impact of systemic long‐term medications for the development of age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä, Reijo Sund, Toni Rikkonen, Kai Kaarniranta   +3 more
wiley   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Normalization of activated partial thromboplastin time and diluted Russell’s viper venom time ratios can be safely omitted in the assessment of lupus anticoagulant

Research and Practice in Thrombosis and Haemostasis
Background: Normalization of lupus anticoagulant (LA) ratios is recommended by both the Clinical & Laboratory Standards Institute and the International Society of Thrombosis and Hemostasis to reduce inter-assay and intra-assay variation.
Adrian Kimiaei, Jovan Antovic, Charlotte Gran   +2 more
doaj   +1 more source

Ruling out lupus anticoagulants with mixing test–specific cutoff assessment and the index of circulating anticoagulant

Research and Practice in Thrombosis and Haemostasis, 2019
Background Lupus anticoagulant (LA) is classified in the antibody family that is recognized in antiphospholipid syndrome. Mixing tests are recommended for LA detection, and either a mixing test–specific cutoff (MTC) or index of circulating anticoagulant (
Osamu Kumano, Gary W. Moore
doaj   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Design and Implementation of an Automated Interpretation Algorithm for Lupus Anticoagulant Functional Testing

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Lupus anticoagulant (LA) testing is essential, albeit complex, in the laboratory diagnosis of antiphospholipid syndrome (APS). Given the multi‐step workflow and the variability introduced by anticoagulant therapy, reagent differences, and interpretive approaches, result interpretation requires expert evaluation.
Chiara Novelli, Arianna Gatti, Flora Ierna, Elena Riccardi, Irene Cuppari   +4 more
wiley   +1 more source

Correlation between APTT mixing test results and inhibitor titers in patients with hemophilia A inhibitor

Zhongguo shuxue zazhi
[Objective] To study the correlation between activated partial thromboplastin time (APTT) mixing test results and the inhibitor titers in hemophilia A inhibitor-positive patients.
WANG Tiantian, CHENG Yan, WANG Hehe, QIAO Cuicui, WANG Jie, ZHONG Guangshang, WANG Xiyuan, ZHANG Xueqin, FANG Yunhai   +8 more
doaj   +1 more source