Results 71 to 80 of about 9,998 (163)

SIRT Family: Biological Functions and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang   +9 more
wiley   +1 more source

PO77 | The clinical awareness of mixing test interpretation in the era of complex reporting algorithm: do we forget the origins?

open access: yesBleeding, Thrombosis and Vascular Biology
Background and Aims: Plasma mixing test is a simple laboratory procedure, which is performed on samples from patients with coagulation screening tests prolonged (mainly the activated partial thromboplastin (APTT), but also the prothrombin time (PT) or ...
doaj   +1 more source

Patients with DVT and primary antiphospholipid syndrome have worse obstetric outcomes than pregnant women with DVT and negative antiphospholipid antibodies: a retrospective cohort study

open access: yesSão Paulo Medical Journal
BACKGROUND: Pregnant women are at an increased risk of thromboembolism compared with non-pregnant women. Venous thrombosis is a manifestation of antiphospholipid syndrome (APS), an autoimmune thrombophilia associated with pregnancy morbidity. OBJECTIVES:
Priscila Guyt Rebelo   +5 more
doaj   +1 more source

Clinical outcome, imaging and histopathological findings of liver cirrhosis in dogs

open access: yesVeterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract Cirrhosis is a severe and irreversible condition resulting from chronic liver injury, characterised by extensive fibrosis and regenerative nodules. This report describes three dogs with cirrhosis. The main clinical findings included ascites, reduced body condition score and inappetence. Anaemia, thrombocytopenia, hypoalbuminaemia, and elevated
Wanderson Feliciano Duarte da Silva   +4 more
wiley   +1 more source

NEWLY DIAGNOSED HEREDITARY FACTOR V DEFICIENCY IN A PATIENT PRESENTING WITH DEEP VEIN THROMBOSIS: A Rare Case

open access: yesHematology, Transfusion and Cell Therapy
Objective: Factor V (FV) is a crucial regulator of hemostasis, functioning as both a procoagulant and an anticoagulant glycoprotein within the coagulation cascade. In plasma, FV exists as an inactive precursor, which is activated by thrombin or factor Xa
Songül Beskisiz Dönen   +3 more
doaj   +1 more source

International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema

open access: yesAllergy, Volume 81, Issue 8, Page 2744-2774, August 2026.
ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas   +128 more
wiley   +1 more source

PO78 | Acquired hemophilia A as a paraneoplastic syndrome: two cases report on a rare coexistence

open access: yesBleeding, Thrombosis and Vascular Biology
Background: Acquired hemophilia, meanwhile, is the most common acquired disease affecting clotting factors. Possible causes that have been empirically described include autoimmune disease (such as rheumatoid arthritis or systemic lupus erythematosus ...
doaj   +1 more source

ACQUIRED HEMOPHILIA A IN A 3-YEAR-OLD PEDIATRIC PATIENT: A CASE REPORT OF RARE AND POTENTIALLY FATAL BLEEDING DISORDER

open access: yesHematology, Transfusion and Cell Therapy
Introduction: Acquired hemophilia A (AHA) is a rare severe autoimmune bleeding disorder with significant morbidity and mortality mainly occurring in older adults (average age 75). The condition is extremely rare in children.
Z Alrajhi, LLE Souza, M Carcao
doaj   +1 more source

Consumed by Abdominal Distention

open access: yes
Arthritis Care &Research, Volume 78, Issue 8, Page 959-966, August 2026.
Abimbola Fadairo‐Azinge   +3 more
wiley   +1 more source

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

open access: yesAllergy, Volume 81, Issue 8, Page 2582-2632, August 2026.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
Torsten Zuberbier   +221 more
wiley   +1 more source

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