Results 61 to 70 of about 9,998 (163)

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome

American Journal of Hematology, Volume 101, Issue 9, Page 2147-2156, September 2026.
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source

The impact of systemic long‐term medications for the development of age‐related macular degeneration

Acta Ophthalmologica, Volume 104, Issue 6, Page 674-681, September 2026.
Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä, Reijo Sund, Toni Rikkonen, Kai Kaarniranta   +3 more
wiley   +1 more source

Haemostatic Parameters in Patients with Behçet’s Disease

Sultan Qaboos University Medical Journal, 2014
Objectives: This study aimed to evaluate the cause of thrombosis in Behçet’s disease (BD) patients, since abnormalities in coagulation and fibrinolytic parameters have shown contradictory results.
Juma K. Alkaabi, David Gravell, Hamood Al-Haddabi, Anil Pathare   +3 more
doaj   +2 more sources

Selective Anti‐Inflammatory Actions of Curcumin on Cytokine Pathways in Major Depressive Disorder

Brain and Behavior, Volume 16, Issue 8, August 2026.
Curcumin partially attenuates IRS/M1/Th1 immune activation in MDD patients ex vivo, but fails to normalize it. Paradoxically, it upregulates immune profiles in healthy controls. Its immunomodulatory effects are state‐dependent, suggesting cautious use in non‐depressed individuals.
Tangcong Chen, Yueyang Luo, Mengqi Niu, Jing Li, Mengdie Li, Yingqian Zhang, Michael Maes   +6 more
wiley   +1 more source

Ciprofloxacin‐Induced Near‐Total Toxic Epidermal Necrolysis Complicated by Upper Gastrointestinal Bleeding: A Case Report With ALDEN‐Based Causality Assessment

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Toxic epidermal necrolysis (TEN) is a rare but life‐threatening mucocutaneous adverse drug reaction characterized by widespread epidermal necrosis and detachment with significant mucosal involvement. We report a case of near total (80%–90%) body surface area TEN in a previously healthy 30‐year‐old man that developed approximately 5 days after ...
Amanuel D. Wakoya, Alemu B. Mesekere, Seid A. abdullahi, Misale B. Tesfaye, Zeynu H. Endris, Zelalem G. Demissie, Tibebu G. Haile   +6 more
wiley   +1 more source

Vobramitamab duocarmazine, an anti–B7‐H3 antibody–drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion

Cancer, Volume 132, Issue 15, 1 August 2026.
Abstract Background Vobramitamab duocarmazine is an investigational antibody–drug conjugate (ADC) targeting B7 homolog 3 (B7‐H3) with a cytotoxic duocarmycin‐based DNA‐alkylating payload. This study evaluated its safety and antitumor activity in advanced solid tumors.
Eugene Shenderov, Manish R. Sharma, Elena Garralda, John Powderly, Iwona Ługowska, Alexander Spira, Marc Cucurull Salamero, Sekwon Jang, Rasha Cosman, John Shen, Wen Xu, Piotr J. Wysocki, Rodryg Ramlau, Emmanuel S. Antonarakis, Andrew J. Weickhardt, Jakub Żołnierek, Emiliano Calvo, Enxu Zhao, Chet Bohac, Ashley Ward, Girish Mallesara   +20 more
wiley   +1 more source

Thromboinflammatory biomarkers in obstetric pathophysiology: Predictive insights into placental insufficiency and feto‐maternal adverse outcomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants

Journal of Clinical Laboratory Analysis, Volume 40, Issue 15, August 2026.
A novel one‐step lupus anticoagulant (LA) assay based on the LA‐sensitivity ratio (LA‐SR) was developed to simplify diagnostic testing and reduce potential interference from anticoagulants. The LA‐SR method showed good agreement with guideline‐based LA testing (dRVVT and/or LA‐sensitive APTT) for the detection of LA and demonstrated limited influence ...
Ayu Hidaka, Risa Kaneshige, Seika Nakamura, Yukari Motoki, Junzo Nojima   +4 more
wiley   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source