Results 41 to 50 of about 29,202 (224)
Lost and found in translation: the value of the human imiquimod model
British Journal of Clinical Pharmacology, EarlyView.Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs +6 more
wiley +1 more source
Nail Disorders in Systemic Conditions
JEADV Clinical Practice, EarlyView.ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley +1 more source
Plasma Cell Mucositis: A 20‐Year Retrospective Review at a Tertiary Center
JEADV Clinical Practice, EarlyView.ABSTRACT Background Plasma cell mucositis (PCM) is a rare, chronic inflammatory condition of mucosal surfaces that is likely underdiagnosed and underreported, with limited data on its clinical characteristics, extracavitary involvement, and treatment outcomes.
Miguel A. Aristizabal‐Torres +4 more
wiley +1 more source
Bullous systemic lupus erythematosus: exceptional and challenging presentation
Iberoamerican Journal of Medicine, 2020 Vesiculobullous lesions can be developed by less than 5% of patients with systemic lupus erythematosus (SLE). Among these lesions, bullous systemic lupus erythematosus (BSLE) is one of the rarest and most challenging cutaneous presentations of the ...
Salem Bouomrani +2 more
doaj +1 more source
A case of cutaneous lupus erythematosus.
Nishi Nihon Hifuka, 1986 約10年前より春夏季にみられる脱毛と加えて9ヵ月前より出没をくりかえす顔面の浸潤性紅斑を有する59才男子例を報告した。組織学的に表皮萎縮, 液状変性とともに真皮上層の浮腫と毛包周囲, 血管周囲性の巣状のリンパ球を主とする細胞浸潤がみられた。電顕的に浸潤細胞と血管内皮細胞内にMTSをみとめ, 表皮内にfilamentous massと真皮内に30μ前後の無構造物質をみとめた。腎症状を欠き, 抗核抗体40倍, 抗DNA抗体80倍と低く, ARA(1982)の診断基準で11項目中4項目をみたした。本症例は北村の不全型としうるが, この型が全身型へ発展する可能性のあるものと考え, 最近のSCLEの概念との関連を考察した。
YAMAKAMI, Atsuko +3 more
openaire +1 more source
Pembrolizumab‐Induced Subacute Cutaneous Lupus Erythematosus: A Case Report
JEADV Clinical Practice, EarlyView.ABSTRACT Subacute cutaneous lupus erythematosus (SCLE) is an increasingly recognized cutaneous immune‐related adverse event of immune checkpoint inhibitors. We report an 83‐year‐old woman who developed pruritic annular and polycyclic plaques 10 weeks after starting pembrolizumab for oropharyngeal squamous cell carcinoma.
Sebastiano Posenato +5 more
wiley +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Systemic Lupus Erythematosus Presented with Bilateral Orbital Edema and Negative Serology
Case Reports in Rheumatology, 2019 Isolated bilateral periorbital edema with negative serology is an extremely rare presentation of cutaneous lupus erythematosus that may lead to eyelid scarring, infection, or even corneal involvement.
Manal Al-Khaldi, Manal Alsabbagh
doaj +1 more source
Real World Use of the IL‐36 Receptor Antagonist Spesolimab: A Systematic Review and Analysis
JEADV Clinical Practice, EarlyView.ABSTRACT Background Spesolimab, an interleukin‐36 receptor antagonist, is approved for the treatment and prevention of generalised pustular psoriasis (GPP) flares. Its use has increasingly been reported in real‐world settings for both GPP and other inflammatory dermatoses.
Sophia A. Mense +4 more
wiley +1 more source
Indian Journal of RheumatologyLupus erythematosus is an autoimmune disease characterised by the formation of various autoantibodies, leading to the involvement of numerous organ systems like the nervous system, renal system, and cutaneous involvement.
Smriti Gupta, Muthu Sendhil Kumaran
doaj +1 more source