Results 11 to 20 of about 295,397 (306)

Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment. [PDF]

Arthritis Care Res (Hoboken)
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histologic features and treatment response.
Fava A, Wagner CA, Guthridge CJ, Macwana S, DeJager W, Munroe ME, Izmirly P, Belmont HM, Diamond B, Davidson A, Utz PJ, Weisman MH, Carlucci PM, Dall'Era M, Kalunian K, Putterman C, Anolik J, Barnas JL, Wofsy D, Kamen D, Furie RA, Rao DA, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus Network, Petri M, Guthridge JM, Buyon J, James JA.   +26 more
europepmc   +2 more sources

Incidence, Prevalence, and Mortality of Lupus Nephritis: A Population‐Based Study Over Four Decades Using the Lupus Midwest Network

Arthritis & Rheumatology, 2022
There is a paucity of population‐based studies investigating the epidemiology of lupus nephritis (LN) in the US and long‐term secular trends of the disease and its outcomes.
M. Hocaoğlu, M. Valenzuela-Almada, Jesse Y Dabit, S. Osei-Onomah, B. Chevet, R. Giblon, Ladan Zand, F. Fervenza, C. Helmick, C. Crowson, A. Duarte-García   +10 more
semanticscholar   +1 more source

Dissecting signalling pathways associated with intrarenal synthesis of complement components in lupus nephritis

RMD Open, 2022
Lupus nephritis is one of the most common and serious complications of systemic lupus erythematosus, attributed to increased morbidity and mortality. The in situ deposition of intrarenal immune complexes promote the accumulation of inflammatory cells and
Samy Hakroush, Björn Tampe, Desiree Tampe   +2 more
doaj   +1 more source

Comparison of clinical features and outcomes between patients with early and delayed lupus nephritis

BMC Nephrology, 2020
Background Lupus nephritis is associated with increased risk of end-stage renal disease (ESRD) and all-cause mortality. We evaluated the clinical features and outcomes of patients with early and delayed lupus nephritis. Methods The medical records of 171
Sung Soo Ahn, Juyoung Yoo, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee   +5 more
doaj   +1 more source

Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis

Lupus Science and Medicine, 2022
Objective Lupus nephritis is one of the most common and serious complications of systemic lupus erythematosus (SLE). Lupus nephritis is a major cause of kidney failure in patients with SLE, attributed to increased morbidity and mortality.
Samy Hakroush, Björn Tampe, Desiree Tampe   +2 more
doaj   +1 more source

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis.

New England Journal of Medicine, 2020
BACKGROUND In adults with active lupus nephritis, the efficacy and safety of intravenous belimumab as compared with placebo, when added to standard therapy (mycophenolate mofetil or cyclophosphamide-azathioprine), are unknown.
R. Furie, B. Rovin, F. Houssiau, A. Malvar, Y. Teng, G. Contreras, Z. Amoura, Xueqing Yu, C. Mok, M. Santiago, A. Saxena, Y. Green, B. Ji, C. Kleoudis, S. Burriss, Carly R. Barnett, D. Roth   +16 more
semanticscholar   +1 more source

In Patients with Membranous Lupus Nephritis, Exostosin-Positivity and Exostosin-Negativity Represent Two Different Phenotypes.

Journal of the American Society of Nephrology, 2021
BACKGROUND In patients with secondary (autoimmune) membranous nephropathy, two novel proteins, Exostosin 1 and Exostosin 2 (EXT1/EXT2), are potential disease antigens, biomarkers, or both.
A. Ravindran, M. Casal Moura, F. Fervenza, S. Nasr, M. Alexander, M. Fidler, Loren P. Herrera hernandez, Pingchuan Zhang, J. Grande, L. Cornell, Louann Gross, V. Negron, Grace E Jenson, B. Madden, M. Charlesworth, S. Sethi   +15 more
semanticscholar   +1 more source

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis

Kidney Diseases, 2023
Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj   +1 more source

Update on Lupus Nephritis: Core Curriculum 2020.

American Journal of Kidney Diseases, 2020
Systemic lupus erythematosus is a multisystem autoimmune disease that commonly affects the kidneys. Lupus nephritis (LN) is the most common cause of kidney injury in systemic lupus erythematosus and a major risk factor for morbidity and mortality.
S. Parikh, S. Almaani, S. Brodsky, B. Rovin   +3 more
semanticscholar   +1 more source

Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis. [PDF]

PLoS ONE, 2013
Lupus nephritis is a cause of significant morbidity in systemic lupus erythematosus (SLE) and its genetic background has not been completely clarified.
Karin Bolin, Johanna K Sandling, Agneta Zickert, Andreas Jönsen, Christopher Sjöwall, Elisabet Svenungsson, Anders A Bengtsson, Maija-Leena Eloranta, Lars Rönnblom, Ann-Christine Syvänen, Iva Gunnarsson, Gunnel Nordmark   +11 more
doaj   +1 more source