Results 31 to 40 of about 295,397 (306)

Systemic lupus erythematosus, lupus nephritis and end-stage renal disease: a pragmatic review mapping disease severity and progression

Lupus, 2020
Objective The understanding of systemic lupus erythematosus (SLE) and lupus nephritis (LN) pathogenesis remains incomplete. This review assessed LN development in SLE, within-LN progression and progression to end-stage renal disease (ESRD).
Anadi Mahajan, J. Amelio, Kerry Gairy, Gavneet Kaur, R. Levy, D. Roth, D. Bass   +6 more
semanticscholar   +1 more source

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

, 2018
Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M, Biasiolo, A, Cappon, A, Cavicchioli, L, Codolo, G, Doria, A., Gatto, M, Ghirardello, A, Luisetto, R, Maggioni, G, Pontisso, P, Saccon, F, Venturini, R   +12 more
core   +2 more sources

Lupus nephritis: clinical presentations and outcomes in the 21st century

Rheumatology, 2020
Lupus nephritis (LN) is a frequent and severe manifestation of SLE. Along the decades, the epidemiology of LN and its clinical presentation have been changing.
M. Gasparotto, M. Gatto, V. Binda, A. Doria, G. Moroni   +4 more
semanticscholar   +1 more source

Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis

Mediators of Inflammation, 2023
Objective. Modified C-reactive protein (mCRP) is known to be involved in the upregulation and amplification of the local inflammatory response. This study investigated the circulating and local levels of mCRP and their relevance to clinicopathological ...
Mo Yuan, Xiao-ling Liu, Ying Tan, Feng Yu, Ming-hui Zhao   +4 more
doaj   +1 more source

Phase II Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis

Arthritis & Rheumatology, 2020
To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN).
Y. Atisha-Fregoso, S. Malkiel, Kristina M. Harris, M. Byron, L. Ding, S. Kanaparthi, William T. Barry, Wendy Gao, Kristin Ryker, Patti Tosta, A. Askanase, S. Boackle, W. Chatham, D. Kamen, David Karp, K. Kirou, S. Sam Lim, B. Marder, M. McMahon, Samir V. Parikh, W. Pendergraft, Amber S. Podoll, A. Saxena, D. Wofsy, B. Diamond, Dawn Smilek, C. Aranow, M. Dall'era   +27 more
semanticscholar   +1 more source

Anti-dsDNA negative and anti-Ro positive lupus nephritis: a report of a rare case

Reumatismo, 2014
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, characterized by an autoantibody response to various nuclear and cytoplasmic antigens.
D. Jain, H.K. Aggarwal, V. Kaverappa, S. Dhayia, P. Jain, S. Yadav   +5 more
doaj   +1 more source

Long Non-Coding RNA TUG1 Gene Polymorphism and TUG1 Expression Level as Molecular Biomarkers of Systemic Lupus Erythematosus and Lupus Nephritis

Non-Coding RNA, 2023
Long non-coding RNA (lncRNA) TUG1 acts as a proto-oncogene, allowing the proliferation of tumor cells, and it has been related to inflammation. Therefore, we aimed in this study to investigate for the first time the role of TUG1 gene polymorphism and the
Gehan Abd-Elfatah Tawfeek, Heba Kasem, Eman Ali Abdallah, Mohammed Almulhim, Abdullah Almulhim, Mohammed Albarqi, Khaled Mohamed Amin Elzorkany   +6 more
doaj   +1 more source

Lupus Nephritis in Children: Novel Perspectives

Medicina, 2023
Childhood-onset systemic lupus erythematosus is an inflammatory and autoimmune condition characterized by heterogeneous multisystem involvement and a chronic course with unpredictable flares.
Marco Pennesi, Simone Benvenuto
doaj   +1 more source

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus [PDF]

, 2015
Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE).
Harnett, M. M., Harnett, W., Pineda, M. A., Rodgers, D. T., Suckling, C. J.   +4 more
core   +1 more source

Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis

Rheumatology & Autoimmunity, 2023
Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by development of autoantibodies and multiorgan involvement. Kidney involvement, termed lupus nephritis, has major impact on life expectancy.
Yi Tong V. Aw, Phillip J. Whiley, Ayla May Lorenzo, Tom Lea‐Henry, Somasundhari Shanmuganandam, Maurice Stanley, Sonia N. Babu, Vicki Athanasopoulos, Jean Cappello, Julia I. Ellyard, Matthew Cook, Carola Vinuesa, Giles Walters, David A. Fulcher, Simon H. Jiang   +14 more
doaj   +1 more source