Results 51 to 60 of about 295,397 (306)

Urinary Soluble CD163: a Novel Noninvasive Biomarker of Activity for Lupus Nephritis.

Journal of the American Society of Nephrology, 2020
BACKGROUND Clinical distinction between patients with lupus nephritis who have active inflammation or chronic kidney damage is challenging. Studies have shown soluble CD163, which derives from cleavage of the CD163 M2c macrophage receptor and can be ...
J. Mejía-Vilet, Xiaolan L Zhang, C. Cruz, Mayra L. Cano-Verduzco, J. Shapiro, H. Nagaraja, L. Morales-Buenrostro, B. Rovin   +7 more
semanticscholar   +1 more source

Neutrophil gelatinase-associated lipocalin is a urine-based biomarker for diagnosing active lupus nephritis

Bangabandhu Sheikh Mujib Medical University Journal
Background: Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE). Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a non-invasive biomarker that may aid in diagnosing active lupus nephritis.
Anthony Chakma, Debatosh Paul, Sheuly Ferdoushi, Minhaj Rahim Choudhury, Md. Saiful Islam   +4 more
doaj   +1 more source

Kidney outcomes for children with lupus nephritis

Pediatric nephrology (Berlin, West), 2020
Systemic lupus erythematosus is a rare lifelong multi-systemic autoimmune condition. Juvenile-onset SLE (JSLE) is recognized to have a more active disease course when compared with adult-onset disease and patients have a worse long-term survival.
L. Oni, R. Wright, S. Marks, M. Beresford, K. Tullus   +4 more
semanticscholar   +1 more source

IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]

, 2019
An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Burmester, Gerd-Rüdiger, Enghard, Philipp, Humrich, Jens, Kloke, Lutz, Kühl, Anja, Riemekasten, Gabriela, Rose, Angelika, von Spee-Mayer, Caroline, Wu, Kaiyin   +8 more
core   +2 more sources

Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis.

JCI Insight, 2020
Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), has both a heterogeneous clinical and pathological presentation.
A. Fava, J. Buyon, C. Mohan, Ting Zhang, H. M. Belmont, P. Izmirly, R. Clancy, J. M. Monroy Trujillo, D. Fine, Yuji Zhang, L. Magder, Deepak A. Rao, A. Arazi, C. Berthier, A. Davidson, B. Diamond, N. Hacohen, D. Wofsy, W. Apruzzese, The Accelerating Medicines Partnership, S. Raychaudhuri, M. Petri   +21 more
semanticscholar   +1 more source

Clinical profile of patients with lupus nephritis

Reumatismo, 2011
To the Editor Lupus nephritis is the strongest predictor of systemic lupus erythematosus (SLE) patient’s morbidity and mortality with a prevalence varying from 31 to 65% according to the studied population (1).
A.C. Schönrock, T.L. Skare
doaj   +1 more source

Tubular Cell and Keratinocyte Single-cell Transcriptomics Applied to Lupus Nephritis Reveal Type I IFN and Fibrosis Relevant Pathways

Nature Immunology, 2019
The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies
E. Der, H. Suryawanshi, Pavel Morozov, Manjunath Kustagi, B. Goilav, Saritha Ranabathou, P. Izmirly, R. Clancy, H. M. Belmont, M. Koenigsberg, M. Mokrzycki, Helen Rominieki, J. Graham, J. Rocca, Nicole Bornkamp, N. Jordan, Emma Schulte, Ming Wu, J. Pullman, Kamil Slowikowski, S. Raychaudhuri, J. Guthridge, J. James, J. Buyon, T. Tuschl, C. Putterman   +25 more
semanticscholar   +1 more source

Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis

Science Translational Medicine, 2020
HIF-1 dictates effector function of infiltrating T cells in lupus, causing tissue damage that can be abrogated by its blockade in murine models. Hypoxic autoimmunity Systemic lupus erythematosus causes severe damage in multiple organs, including the ...
Ping-Min Chen, Parker C. Wilson, J. Shyer, M. Veselits, H. Steach, Can Cui, G. Moeckel, M. Clark, J. Craft   +8 more
semanticscholar   +1 more source

Coincidental light chain induced proximal tubulopathy with lupus nephritis: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background We report a case of light chain proximal tubulopathy associated with lupus nephritis in a patient known to have systemic lupus erythematosus. The kidney can be injured in several ways in any of these disorders. Light chain proximal tubulopathy
Wael Mostafa Hamza, Ahmed Mohammed AlEssa   +1 more
doaj   +1 more source

Update on Lupus Nephritis: Looking for a New Vision

Nephron, 2020
Lupus nephritis (LN) is one of the most common manifestations of systemic lupus erythematosus (SLE), affecting approximately 40% of patients with lupus.
E. Morales, M. Galindo, Hernando Trujillo, M. Praga   +3 more
semanticscholar   +1 more source