Results 61 to 70 of about 157 (83)

Lipidomics of phospholipase A₂ reveals exquisite specificity in macrophages. [PDF]

J Lipid Res
Murawska GM, Armando AM, Dennis EA.
europepmc   +1 more source

Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies. [PDF]

Commun Biol
Bittenbinder MA, van Thiel J, Cardoso FC, Casewell NR, Gutiérrez JM, Kool J, Vonk FJ.   +6 more
europepmc   +1 more source

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. [PDF]

Proc Natl Acad Sci U S A
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu LO, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR.   +13 more
europepmc   +1 more source

Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A₂ inhibitors. [PDF]

Adv Biol Regul, 2020
Mouchlis VD, Mu C, Hammons R, Dennis EA.
europepmc   +1 more source

Varespladib Inhibits the Phospholipase A₂ and Coagulopathic Activities of Venom Components from Hemotoxic Snakes. [PDF]

Biomedicines, 2020
Xie C, Albulescu LO, Still KBM, Slagboom J, Zhao Y, Jiang Z, Somsen GW, Vonk FJ, Casewell NR, Kool J.   +9 more
europepmc   +1 more source

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System. [PDF]

Int J Mol Sci, 2020
Knuplez E, Marsche G.
europepmc   +1 more source

Articles You May Have Missed. [PDF]

J Med Toxicol, 2018
Goodnough R, Murphy CE, Smollin C, Repplinger D.   +3 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Varespladib (LY315920) prevents neuromuscular blockage and myotoxicity induced by crotoxin on mouse neuromuscular preparations

Toxicon, 2021
Varespladib (LY315920) is a synthetic phospholipase A2 (PLA2) inhibitor that has been demonstrating antiophidic potential against snake venoms that present PLA2 neurotoxins. In this study, we evaluate the capacity of Varespladib to inhibit the neuromuscular effects of crotoxin (CTX), the main toxic component of Crotalus durissus terrificus snake venom,
Walter Cavalcante, Consuelo L Fortes-Dias, Emylle Pinto   +2 more
exaly   +3 more sources

Varespladib (LY315920) inhibits neuromuscular blockade induced by Oxyuranus scutellatus venom in a nerve-muscle preparation

Toxicon, 2020
The phospholipase A2 (PLA2) inhibitors varespladib (LY315920) and its orally available derivative methyl-varespladib (LY333013) have been proposed as potential therapies for the treatment of snakebite envenomings in which toxicity depends on the action of PLA2s.
José Maria Gutierrez, Yoko Oshima-Franco, Lewin Mr   +2 more
exaly   +3 more sources

Varespladib (LY315920) neutralises phospholipase A2 mediated prothrombinase-inhibition induced by Bitis snake venoms

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 2020
Anticoagulant toxicity is a common function of venoms produced by species within the Bitis genus. Potent inhibition of the prothrombinase complex is an identified mechanism of action for the dwarf species B. cornuta and B. xeropaga, along with some localities of B. atropos and B. caudalis.
Bryan Fry, Nicholas Youngman, Andrew A Walker   +2 more
exaly   +6 more sources